RAD18

  • Official Full Name

    RAD18 RAD18 homolog (S. cerevisiae)

  • Overview

    The Rad6-Rad18 pair of genes plays a critical role in post-replication repair of damaged DNA. Rad6 protein functions as an E2 enzyme and Rad18 as a ubiquitine ligase.

  • Synonyms

    RAD18;RAD18 homolog (S. cerevisiae);E3 ubiquitin-protein ligase RAD18;RNF73;hHR18;hRAD18;RING finger protein 73;RAD18, S. cerevisiae, homolog;postreplication repair protein RAD18;postreplication repair protein hRAD18p

Recombinant Proteins

  • Zebrafish
  • Chicken
  • Human
  • Mouse
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • E.coli
  • In Vitro Cell Free System
  • Mammalian cells
  • HEK293T
  • His
  • Non
  • His&SUMO
  • His&Fc&Avi
  • Flag
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
RAD18-10488Z Recombinant Zebrafish RAD18 Mammalian Cell Zebrafish His
RAD18-2315C Recombinant Chicken RAD18 Mammalian Cell Chicken His
RAD18-29578TH Recombinant Human RAD18 Wheat Germ Human Non 495 amino acids
RAD18-29579TH Recombinant Human RAD18 Wheat Germ Human Non 99 amino acids
RAD18-2561HCL Recombinant Human RAD18 293 Cell Lysate HEK293 Human Non
RAD18-1151H Recombinant Human RAD18 Protein (1-495 aa), His-SUMO-tagged E.coli Human His&SUMO 1-495 aa
RAD18-1848H Recombinant Human RAD18 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
RAD18-1848H-B Recombinant Human RAD18 Protein Pre-coupled Magnetic Beads HEK293 Human
RAD18-421HF Active Recombinant Full Length Human RAD18 Protein In Vitro Cell Free System Human Full L. 495 amino acids
RAD18-529HFL Active Recombinant Full Length Human RAD18 Protein, C-Flag-tagged Mammalian cells Human Flag Full L.
Rad18-5347M Recombinant Mouse Rad18 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK

    Involved Pathway

    RAD18 involved in several pathways and played different roles in them. We selected most pathways RAD18 participated on our site, such as DNA Damage Bypass,DNA Repair,Recognition of DNA damage by PCNA-containing replication complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    DNA Repair TDP2B,PPP4R2,CHEK2,BRE,DCLRE1A,TP53BP1,GEN1,BARD1,ERCC8,APITD1
    DNA Damage Bypass USP10,UBE2L6,USP43,DTL,KIAA0101,SPRTN,DDB1,POLD3,USP43A,MAD2L2
    Recognition of DNA damage by PCNA-containing replication complex ZBTB32,DTL

    Protein Function

    RAD18 has several biochemical functions, for example, Y-form DNA binding,damaged DNA binding,ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD18 itself. We selected most functions RAD18 had, and list some proteins which have the same functions with RAD18. You can find most of the proteins on our site.

    Function Related Protein
    protein complex binding PDZK1,CDK4,PROS1,TELO2,ING2,LZTFL1,KAT2B,NDUFA4,NCKAP1,UQCRC2
    polyubiquitin binding PSMD4B,PSMD4A,PSMD4,SHARPIN,TNIP2,TNIP3,DNAJB2,UBQLN1,BRE,THRSP
    protein binding MRC1,SPTSSA,CD99L2,MCPH1,SPOP,NRIP2,PFN2,NHLH2,TMEM66,GAGE1
    zinc ion binding BTR18,QPCTLA,VPS29,MT1A,AKAP8,KMT2A,ZNF346,TRIM35-20,DUSP12,LMO7A
    ubiquitin protein ligase activity UBE2N,UBE2Z,RNF34,MED27,NEDD4,COP1,RNF146,PRPF19,TRIM63,STUB1
    ligase activity MARCH3,RNF114,RNF135,FPGS,E4F1,DTX2,NEDD4L,GATB,UBE2IA,ACSF2
    single-stranded DNA-dependent ATPase activity DNA2,RAD51
    Y-form DNA binding WRN,MSH3,MSH2,MEN1
    ubiquitin protein ligase binding PRKAR2B,UBE2S,PIAS4,BAG4,NLK,UCHL1,TRAF3,XRCC5,TRIM37,GPI1

    Interacting Protein

    RAD18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD18 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD18.

    TAX1BP1;UBE2A;UBE2B;Map3k1;Smc6;TRIM23;UBE2I;DZIP3;MLKL;TSG101;PCGF6;TRIM8;SRGAP3;HK2;CREM

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