TSHR
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Official Full Name
thyroid stimulating hormone receptor -
Overview
Thyroid-stimulating hormone (TSH); is a glycoprotein hormone1 that regulates the endocrine function of the thyroid gland.2 The most important controller of TSH secretion is thyroid-releasing hormone. Thyroid-releasing hormone is secreted by hypothalamic n -
Synonyms
TSHR;thyroid stimulating hormone receptor;thyrotropin receptor;LGR3;TSH-R;thyrotropin receptor-I, hTSHR-I;seven transmembrane helix receptor;thyroid-stimulating hormone receptor;thyroid stimulating hormone receptor, isoform 2;CHNG1;hTSHR-I;MGC7
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Rat
- Zebrafish
- Sheep
- Felis catus
- Bovine
- Dog
- Mouse
- E.coli
- CHO
- HEK293
- Mammalian Cell
- HEK293T
- E.coli expression system
- E. coli
- Insect cell
- Mamanlian cells
- His
- GST
- Fc
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
TSHR involved in several pathways and played different roles in them. We selected most pathways TSHR participated on our site, such as cAMP signaling pathway,Neuroactive ligand-receptor interaction,Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSHR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of lipolysis in adipocytes | AKT2,GNAI2,Adcy4,IRS1,GNAI1,INS2,PIK3R1,PRKACG,PIK3CA,PTGER3 |
| cAMP signaling pathway | PIK3CD,PIK3CA,GRIN3B,ATP1A2,EP300,PRKACG,MLLT4,CAMK2B,PDE4B,PTGER3 |
| ne thyroid disease | HLA-DQB1,HLA-E,CD86,IFNA8,IFNA17,HLA-DOA,FASLG,FAS,IFNA4,HLA-DQA2 |
| Thyroid hormone synthesis | HSPA5,CANX,SLC26A4,FXYD2,LRP2,TG,DUOXA2,ITPR3,PRKACA,PRKCB |
| Autoi | CD40LG,Il2,IL5,HLA-DQB1,Ifna11,Ifna15,H2-Q10,HLA-DMA,HLA-DRB1,CD86 |
| Neuroactive ligand-receptor interaction | PRSS3,LEPB,LEPR,GPR50,GALR3,TAAR9,F2RL1.2,HTR7,P2RY11,GRIA4B |
Protein Function
TSHR has several biochemical functions, for example, G-protein coupled peptide receptor activity,protein binding,thyroid-stimulating hormone receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TSHR itself. We selected most functions TSHR had, and list some proteins which have the same functions with TSHR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| thyroid-stimulating hormone receptor activity | PAX8 |
| protein binding | CTBP2,LLGL2,CCDC116,RHOXF2,ITGB7,AXIN1,KATNBL1,C6orf226,KCTD9,CEP104 |
| G-protein coupled peptide receptor activity | CYSLTR1,FSHR,GRPR,RXFP3,MC1R,LTB4R,RXFP3.2B,MCHR2,RXFP4,CYSLTR2 |
Interacting Protein
TSHR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSHR here. Most of them are supplied by our site. Hope this information will be useful for your research of TSHR.
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