Recombinant Human TSHR

• Cat.No.: TSHR-3451H
• Product Overview: Recombinant human TSHR (66 kDa) protein was expressed in E. coli with His-tag.

Specification

• Description: The protein encoded by this gene is a membrane protein and a major controller of thyroid cellmetabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity ismediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Each vial contains Tris-HCl (pH7.4 ± 0.2), with 0.02% NaN3.
• Molecular Mass: 66 kDa
• AA Sequence: GMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHEMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL
• Purity: > 90%
• Applications: ELISA, SDS-PAGE
• Storage: Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: TSHR thyroid stimulating hormone receptor [ Homo sapiens (human) ]
• Official Symbol: TSHR
• Synonyms: TSHR; LGR3; CHNG1; hTSHR-I; thyroid stimulating hormone receptor; thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; seven transmembrane helix receptor; thyroid stimulating hormone receptor, isoform 2
• Gene ID: 7253
• mRNA Refseq: NM_000369
• Protein Refseq: NP_000360
• MIM: 603372
• UniProt ID: P16473