Recombinant Human TSHR, GST-tagged

• Cat.No.: TSHR-3450H
• Product Overview: Recombinant Human TSHR was expressed as gst-tagged fusion protein by E.Coli and puri?ed by GSH-sepharose.

Specification

• Description: The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-253 a.a.
• AA Sequence: 1-253aa
• Storage: The protein is stored in PBS bu?er at -20 oC. Repeated freeze-thaw cycles should be avoided.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: TSHR?thyroid stimulating hormone receptor [?Homo sapiens?(human) ]
• Official Symbol: TSHR
• Synonyms: TSHR; LGR3; CHNG1; hTSHR-I; thyroid stimulating hormone receptor; thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; seven transmembrane helix receptor; thyroid stimulating hormone receptor, isoform 2
• Gene ID: 7253
• mRNA Refseq: NM_000369
• Protein Refseq: NP_000360
• MIM: 603372
• UniProt ID: P16473
• Chromosome Location: 14q31
• Pathway: Arf6 signaling events; Autoimmune thyroid disease; G alpha (s) signalling events
• Function: protein binding; thyroid-stimulating hormone receptor activity