TP53
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Official Full Name
tumor protein p53 -
Overview
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013] -
Synonyms
TP53;tumor protein p53;P53;BCC7;LFS1;TRP53;cellular tumor antigen p53;antigen NY-CO-13;tumor protein 53;phosphoprotein p53;p53 tumor suppressor;mutant tumor protein 53;transformation-related protein 53
Recombinant Proteins
- Monkey
- Human
- Cynomolgus
- Rhesus macaque
- Rat
- Chicken
- Zebrafish
- Mouse
- E.coli
- Sf9 Insect Cell
- HEK293
- Insect Cell
- Mammalian Cell
- Mammalian cells
- HEK293T
- Insect Cells
- Yeast
- Insect cells
- E. coli
- GST
- His
- Non
- Myc&DDK
- Flag
- His&Avi
- His&Fc&Avi
- N-MBP & C-His
- His&SUMO
- Strep
Involved Pathway
TP53 involved in several pathways and played different roles in them. We selected most pathways TP53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with TP53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bladder cancer | HBEGF,MMP1A,MAPK3,CDH1,DAPK3,THBS1,NRAS,MMP2,FGFR3,CXCL8 |
| Viral carcinogenesis | MDM2,HLA-B,RBL1,GTF2B,RB1,HDAC1,ACTN1,CDK1,HIST1H2BQ,YWHAB |
| Sphingolipid signaling pathway | LOC100328615,LASS1,ASAH1,FYN,SGMS2,CERS4,PPP2R5D,GNAI3,MAP2K1,PPP2R2D |
| Hepatitis B | TLR2,AKT2,VDAC3,NRAS,HBXIP,IFNAR1,PIK3CG,STAT4,CASP10,KRAS |
| Cell cycle | CDKN2D,MYC,LIN9,TFDP2,SMARCA5,CSNK2B,CENPE,MCM3,MCM5,CDC14B |
| Measles | TRAF6,GSK3B,IL6,IFNGR1,STAT3,FYN,SLAMF1,AKT2,RCHY1,AKT1 |
| Small cell lung cancer | PIK3CA,LAMA4,APAF1,BIRC2,RXRA,LAMA3,IKBKB,CCNE2,CKS2,IKBKG |
| Amyotrophic lateral sclerosis (ALS) | PPP3CB,PPP3CC,APAF1,CASP12,GRIN2C,RAC1,MAPK13,GRIN2D,MAPK11,GPX1 |
| Basal cell carcinoma | PTCH2,WNT7B,WNT3,DVL1,AXIN2,WNT2,WNT7A,TRP53,FZD2,Shh |
Protein Function
TP53 has several biochemical functions, for example, ATP binding,DNA binding,RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TP53 itself. We selected most functions TP53 had, and list some proteins which have the same functions with TP53. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription factor binding | CREBBP,TRP53,GATA5,GATA3,ID4,PITX2,GATA4,NFATC1,MIXL1,T |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | SFPI1,EBF4,SP1,GATA3,ETV4,FOXJ1,NFYC,ETV6,NRL,IRF4 |
| histone deacetylase regulator activity | MAPK8,TRP53,NCOR1 |
| transcription factor activity, sequence-specific DNA binding | MYPOP,HMGB2,ZNF493,TLX2,TBX10,NFKB1,HSF2,E2F4,HELT,L3MBTL4 |
| RNA polymerase II core promoter sequence-specific DNA binding | MAZ,GATA6,STAT5A,TFAP2B,SMAD1,SPI1,RUVBL2,YAP1,ZNF277,EP300 |
| p53 binding | TAF3,HSPD1,ZFP385C,TRP63,PTTG1IP,KDM1A,BLM,AXIN1,SETD7,GATA1 |
| protein heterodimerization activity | UGT1A6A,ADORA2A,TAL1,RRAGA,GAD2,ATF6,BCL11A,YWHAH,MID2,HIST1H2A9 |
| protein self-association | TTN,CCL5,S100A7A,ADAM8,TMEM43,SYP,DVL2,CTSC,MDH2,ZKSCAN17 |
| ATP binding | MYHC4,PDGFRB,CHEK2,NLK2,ABCF1,ATP1A4,DNAJA2,DDX20,KIF12,ZAP70 |
Interacting Protein
TP53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TP53 here. Most of them are supplied by our site. Hope this information will be useful for your research of TP53.
MDM2
TP53 Related Signal Pathway
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References
- Sadahira, Y; Sugihara, T; et al. WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome. VIRCHOWS ARCHIV 466:343-350(2015).
- Fuentes-Raspall, MJ; Caragol, I; et al. Apoptosis for prediction of radiotherapy late toxicity: lymphocyte subset sensitivity and potential effect of TP53 Arg72Pro polymorphism. APOPTOSIS 20:371-382(2015).
