RORC
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Official Full Name
RAR-related orphan receptor C -
Overview
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
RORC;RAR-related orphan receptor C;TOR;RORG;RZRG;NR1F3;RZR-GAMMA;nuclear receptor ROR-gamma;nuclear receptor RZR-gamma;retinoic acid-binding receptor gamma;retinoid-related orphan receptor gamma;RAR-related orphan receptor C, isoform a;RAR-related orphan nuclear receptor variant 2;nuclear receptor subfamily 1 group F member 3
Recombinant Proteins
- Human
- Mouse
- Insect Cells
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- Yeast
- In Vitro Cell Free System
- GST
- His
- His&SUMO
- Flag&His
- DDK&Myc
- Non
- Flag&His&Twin Strep
- Avi&Fc&His
- Flag
Involved Pathway
RORC involved in several pathways and played different roles in them. We selected most pathways RORC participated on our site, such as Circadian rhythm,Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with RORC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Circadian rhythm | FBXL3,RORB,CLOCK,PRKAA2,ARNTL,CRY1,CUL1,PRKAG3,PRKAB2,RORA |
| Inflammatory bowel disease (IBD) | HLA-DRB1,NFKB1,IL23,IL21R,HLA-DRB5,IL22,MAF,IL4,TGFB2,HLA-DRB3 |
Protein Function
RORC has several biochemical functions, for example, DNA binding,RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding,oxysterol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RORC itself. We selected most functions RORC had, and list some proteins which have the same functions with RORC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | ZNF287,HIC1,GABPB1,SCAND1,ATF4,SMAD3,PURBA,PRDM1,TFCP2,CREB3L3L |
| steroid hormone receptor activity | HNF4G,PGR,VDRB,THRA,NR1D2,HNF4A,PAQR7,PPARD,PAQR8,VDR |
| zinc ion binding | SEC24D,PHC1,BTY,ALAD,ZNF622,KDM5B,TRAF6,AGBL4,PEX12,GCM1 |
| transcription factor activity, direct ligand regulated sequence-specific DNA binding | RORA |
| oxysterol binding | OSBP,GPR183,OSBPL5,RORA |
| DNA binding | SCRT2,NR4A2A,TFIP11,APLP2,RPS15,TERFA,PIAS1,ZFP239,ZFP367,HOMEZA |
| protein binding | VAMP8,SPAG9,ITGB2,NUDT18,CLK4,MPP1,OCA2,RRS1,POU1F1,FGFR4 |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | ESR2,PPARAB,NR4A1,PPARA,NR2F1,NR2F1A,NR2F5,RORCB,NR5A2,NR5A1A |
| sequence-specific DNA binding | ZKSCAN1,HOXA1,BCL11AB,RXRAB,HOXD1,FOXL1,ZFP161,FOXP3,TLX3B,SFPI1 |
Interacting Protein
RORC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RORC here. Most of them are supplied by our site. Hope this information will be useful for your research of RORC.
Clock;Arntl;NCOA1;CREBBP;PPARGC1A;20-hydroxycholesterol;25-hydroxycholestero;(22r)-22-hydroxycholesterol;BHLHE40;Per2;EVI2A;PPP2R1A;PPP2R1B;PPP1CC;PPP1CA;PPP1CB;PPP2CA
RORC Related Signal Pathway
Resources
Research Area
Apoptosis Intracellular KinasesMultiple Sclerosis and Myelin Related Molecules
Parkinson's Disease Related Molecules
Intracellular Kinases in the Akt Pathway
Growth Hormone/IGF-I Axis
ROS and Stress Resistance
Negative Regulators of the Jak/STAT Pathway
Positive Regulators of the Jak/STAT Pathway
gamma delta T Cells
Natural Killer T (NKT) Cells
Th17 Cells
Related Services
Related Products
References
- Lubberts, E; et al. Role of T Lymphocytes in the Development of Rheumatoid Arthritis. Implications for Treatment. CURRENT PHARMACEUTICAL DESIGN 21:142-146(2015).
- Balabko, L; Andreev, K; et al. Increased expression of the Th17-IL-6R/pSTAT3/BATF/Ror gamma T-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung. SCIENTIFIC REPORTS 4:-(2014).
