RHOB
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Official Full Name
ras homolog family member B -
Overview
Rho family small GTPases, including Rho, Rac and cdc42, act as molecular switches, regulating processes such as cell migration, adhesion, proliferation and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze t -
Synonyms
RHOB;ras homolog family member B;ARH6, ARHB, ras homolog gene family, member B;rho-related GTP-binding protein RhoB;MST081;oncogene RHO H6;RHOH6;h6;rho cDNA clone 6;Aplysia RAS-related homolog 6;ras homolog gene family, member B;ARH6;AR
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Chicken
- Cynomolgus
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
RHOB involved in several pathways and played different roles in them. We selected most pathways RHOB participated on our site, such as Androgen receptor signaling pathway,Axon guidance,Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with RHOB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G alpha (12/13) signalling events | RHOAE,ABR,TIAM2,GNA13,ARHGEF18A,ARHGAP4A,PLEKHG2,AKAP13,KALRNB,ECT2 |
| GPVI-mediated activation cascade | G6b,PDPN,FCER1GL,CLEC1B,C6orf25,PIK3R6,LCP2A,RHOGA |
| GPCR downstream signaling | OPN1LW2,RAMP3,LTB4R,CALCB,CXCL11.8,ABHD6B,GAL,SSTR1,OBSCN,ADM2A |
| Axon guidance | CXCR4,ARPC1B,LIMK1,KDR,CAP1,FGF18B,EFNA2A,SLIT2,ABLIM2,DUSP6 |
| Hemostasis | WDR1,NFE2,DOCK10,SLC8A2A,F13A1B,SLC16A8,ZFPM1,IRF2,SCG3,F9A |
| Developmental Biology | PEA15A,DUSP6,EGR2,UNC5D,EFNB3B,CSNK2A2,HELZ2,COL6A1,SIAH2,AP2A1 |
| Focal adhesion | MAPK8B,ITGB1B.2,PXNA,RAP1AA,COL27A1A,FYNB,ARHGAP35,PIK3CA,TLN2A,RAC2 |
| Androgen receptor signaling pathway | NR0B2A,EGFR,TGFB1I1,PNRC1,PARK7,NCOA2,DSTN,SVILA,CARM1,SMARCE1 |
Protein Function
RHOB has several biochemical functions, for example, GDP binding,GTP binding,GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RHOB itself. We selected most functions RHOB had, and list some proteins which have the same functions with RHOB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GDP binding | SRP54B,RAB21,PIGC,RRAGC,RAB27A,RAB11B,RAB14,RAB9B,ARF1,RAB18 |
| protein binding | NADSYN1,C21orf56,FZD7,USP18,TNPO1,EPB49,CCDC68,CHMP5,ZFPL1,FRA10AC1 |
| GTP binding | RASD1,EFTUD2,RHOUB,HRAS,ARL4CB,GUF1,RAB1BB,RAB32A,ARFRP1,RALAB |
| GTPase activity | RAB11BA,TUBD1,GIMAP7,TUBA1L2,GNAI3,RAB32A,DNM3,EIF5,TUBA2,GNB2 |
Interacting Protein
RHOB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RHOB here. Most of them are supplied by our site. Hope this information will be useful for your research of RHOB.
SMURF1;TNFAIP1;DIAPH1;DAAM1;Fnta;PHGDH;EIF1B;PRAF2;NQO2;NME2;DUT;FBN1;NEK2;ARHGDIA
RHOB Related Signal Pathway
Resources
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References
- Chinestra, P; Olichon, A; et al. Generation of a Single Chain Antibody Variable Fragment (scFv) to Sense Selectively RhoB Activation. PLOS ONE 9:-(2014).
- Tiburcio, MGS; Pinheiro, NM; et al. GTPases Rho distribution in intraepithelial and invasive neoplasias of the uterine cervix. EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY 35:284-288(2014).
