RET
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Official Full Name
ret proto-oncogene -
Overview
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008] -
Synonyms
RET;ret proto-oncogene;PTC;MTC1;HSCR1;MEN2A;MEN2B;RET51;CDHF12;CDHR16;RET-ELE1;proto-oncogene tyrosine-protein kinase receptor Ret;proto-oncogene c-Ret;receptor tyrosine kinase;RET transforming sequence;cadherin family member 12;hydroxyaryl-protein kinase;cadherin-related family member 16;ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Aspergillus restrictus
- Insect Cells
- HEK293
- Sf21 Cells
- Mammalian Cells
- Sf9 Cells
- CHO
- Human Cells
- E.coli
- GST&His
- His
- Non
- GST
- Flag&His
- Flag
- Avi&Fc&His
- His&Myc
Involved Pathway
RET involved in several pathways and played different roles in them. We selected most pathways RET participated on our site, such as Endocytosis,Pathways in cancer,Thyroid cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with RET were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | CHMP2BB,TGFB1,KITB,ARRB1,TGFB3,LDLRA,FAM125A,CXCR4A,PIP5K1BB,SNF8 |
| Central carbon metabolism in cancer | FGFR2,LDHA,SLC7A5,PIK3CA,FGFR1,SIRT6,PKM2,PFKM,PFKL,PGAM2 |
| Thyroid cancer | NTRK1,PAX8,PPARG,RXRB,MAP2K2,TPR,TPM3,NRAS,NCOA4,KRAS |
| Pathways in cancer | RAC3,HGF,RALBP1,FGF13,IGF1,CASP8,ARAF,BRCA2,FGF4,NKX3 |
Protein Function
RET has several biochemical functions, for example, ATP binding,calcium ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RET itself. We selected most functions RET had, and list some proteins which have the same functions with RET. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane receptor protein tyrosine kinase activity | FGFR1A,CSF1RA,INSRR,IGF1RB,ROS1,ERBB4,FGFR1B,NTRK3A,NPTN,KITA |
| ATP binding | MYLK,MAGI3,MAP2K5,UBE2I,PRKCH,BMPR1B,TRIO,MCCC1,ATAD2B,YTHDC2 |
| protein binding | ATP5F1,TRP53,EIF5A2,COQ9,ROBO2,SUN2,TPX2,RNF19B,CNTROB,ZNF133 |
| protein tyrosine kinase activity | FER,KIAA1804,FYN,TNK1,FGFR1A,WEE1,PTK7,MAP3K11,NTRK2B,MAP2K7 |
| receptor activity | FPR1,NOTCH1A,KLRG1,GRIK5,CSF2RB,ABP1,TNFRSF9,OGFRL1,DARC,ICAM1 |
| calcium ion binding | AP1S2,RHBDL3,MACF1,SLIT3,PCDH2G7,EFCC1,ENPP2,ITIH1,DGKA,FBN1 |
Interacting Protein
RET has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RET here. Most of them are supplied by our site. Hope this information will be useful for your research of RET.
CBL;Sh2b1;PLCG1;STAT3;NOTCH2NL;Plcg1
Resources
Research Area
Cancer Drug TargetsOther Cytokines & Receptors
Receptor Tyrosine Kinases (RTKs)
ALS Related Molecules
Receptor Tyrosine Kinases (RTKs) in the Akt Pathway
Oncoprotein-Growth Factor Receptors
Related Services
Related Products
References
- Gurzu, S; Ciortea, D; et al. The immunohistochemical profile of granular cell (Abrikossoff) tumor suggests an endomesenchymal origin. ARCHIVES OF DERMATOLOGICAL RESEARCH 307:151-157(2015).
- Doberstein, K; Harter, PN; et al. Antibody therapy to human L1CAM in a transgenic mouse model blocks local tumor growth but induces EMT. INTERNATIONAL JOURNAL OF CANCER 136:E326-E339(2015).
