Recombinant Human ret proto oncogene Protein, Flag tagged

• Cat.No.: RET-13H
• Product Overview: Recombinant protein of human ret proto-oncogene (RET), transcript variant 2, residues 29-635aa, with C-terminal DDK tag, expressed in Sf9.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: Flag
• Protein Length: 29-635 aa
• Description: This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis.
• Tag: C-Flag
• Molecular Mass: 67.78 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Notes: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Storage Buffer: 50 mM Tris-HCl, 100 mM glycine, pH 8.0, 10% glycerol
• Concentration: > 0.05 μg/μL as determined by microplate BCA method

Gene Information

• Gene Name: RET ret proto-oncogene [ Homo sapiens (human) ]
• Official Symbol: RET
• Synonyms: RET; ret proto-oncogene; PTC; MTC1; HSCR1; MEN2A; MEN2B; CDHF12; CDHR16; RET-ELE1; proto-oncogene tyrosine-protein kinase receptor Ret; RET receptor tyrosine kinase; cadherin family member 12; cadherin-related family member 16; proto-oncogene c-Ret; rearranged during transfection; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease); EC 2.7.10.1
• Gene ID: 5979
• mRNA Refseq: NM_020975
• Protein Refseq: NP_066124
• MIM: 164761
• UniProt ID: P07949