POLK
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Official Full Name
polymerase (DNA directed) kappa -
Overview
External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a;variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the;replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the;replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage;bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007;(PubMed 17317631)). -
Synonyms
POLK;polymerase (DNA directed) kappa;DINB1;DNA polymerase kappa;DINB protein;DINP;POLQ
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
POLK involved in several pathways and played different roles in them. We selected most pathways POLK participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fanconi Anemia Pathway | FANCG,USP1,FANCC,FANCF,RPA2,RPA1,FANCB,FAN1,DCLRE1A,POLN |
Protein Function
POLK has several biochemical functions, for example, DNA-directed DNA polymerase activity,damaged DNA binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLK itself. We selected most functions POLK had, and list some proteins which have the same functions with POLK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | NT5M,GPATCH8,TEC,UNC13A,VPS18,MCM2,RNF220A,ZNF19,FGD4,ZSWIM7 |
| DNA-directed DNA polymerase activity | POLD2,PAPD7,POLH,MYBBP1A,POLG,POLE3,POLN,CCDC111,DNTT,POLE4 |
| damaged DNA binding | CREBBP,ERCC3,TP53,XRCC1,RUVBL2,H2AFX,PCNA,EP300,OGG1,TP73 |
Interacting Protein
POLK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLK here. Most of them are supplied by our site. Hope this information will be useful for your research of POLK.
q7ard3_yerpe;TIA1;SYNPO2;H3F3B;PIAS1;CD2BP2;STAT6;PLXNA3;RAD51;NOLC1;UBE2V2;ZCCHC6;FIP1L1;SBSN;PCGF5;CD99L2;Kctd5;APOL2;RBM4
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References
- Hilliard, VC; Frey, MR; et al. TNF-alpha converting enzyme-mediated ErbB4 transactivation by TNF promotes colonic epithelial cell survival. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 301:G338-G346(2011).
- Seki, M; Gearhart, PJ; et al. DNA polymerases and somatic hypermutation of immunoglobulin genes. EMBO REPORTS 6:1143-1148(2005).
