Recombinant Human PIK3R1, His-tagged
Cat.No. : | PIK3R1-29588TH |
Product Overview : | Recombinant full length Human PI 3 Kinase p85 alpha with N terminal His tag, expressed in a Baculovirus infected Sf9 cell expression system, amino acids 1-724, 86kDa. |
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Description : | Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. |
Conjugation : | HIS |
Tissue specificity : | Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level). |
Form : | Liquid |
Storage buffer : | Preservative: 150mM ImidazoleConstituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 2mM DTT, 0.1mM PMSF, pH 7.0 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the PI3K p85 subunit family.Contains 1 Rho-GAP domain.Contains 2 SH2 domains.Contains 1 SH3 domain. |
Protein length : | 1-724 a.a. |
Full Length : | Full L. |
Gene Name | PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [ Homo sapiens ] |
Official Symbol | PIK3R1 |
Synonyms | PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); phosphatidylinositol 3-kinase regulatory subunit alpha; GRB1; p85; p85 ALPHA; |
Gene ID | 5295 |
mRNA Refseq | NM_001242466 |
Protein Refseq | NP_001229395 |
MIM | 171833 |
Uniprot ID | P27986 |
Chromosome Location | 5q13.1 |
Pathway | 3-phosphoinositide biosynthesis, conserved biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; |
Function | 1-phosphatidylinositol binding; ErbB-3 class receptor binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; |
Not For Human Consumption!
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