PFN2
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Official Full Name
profilin 2 -
Overview
The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. -
Synonyms
PFN2;profilin 2;profilin-2;D3S1319E;PFL;PFN 2;Profilin II;Profilin2;ProfilinII;OTTHUMP00000216204;OTTHUMP00000216339;OTTHUMP00000216340;OTTHUMP00000216346
Recombinant Proteins
- Zebrafish
- Mouse
- Human
- Chicken
- Rat
- Cynomolgus
- Mammalian Cells
- E.coli
- HEK293
- His
- T7
- Non
- N-MBP & C-His
- N-SUMO & N-His
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PFN2 involved in several pathways and played different roles in them. We selected most pathways PFN2 participated on our site, such as Rap signaling pathway,Regulation of actin cytoskeleton,Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Salmonella infection | TLR4BA,TLR5B,MAPK10,CCL3L1,MAPK12A,IL6,CXCL8B.3,ROCK2B,RHOG,DYNC1I2A |
| Regulation of Actin Cytoskeleton | SCINLA,PIP5K1AA,FGF20B,RRAS,MSNB,ITGB3,PIP4K2A,ACTN3,RAC1B,PPP1CA |
| Shigellosis | PFN1,RIPK2,ELMO3,ATG5,MAPK9,FBXW11,ARPC5L,HCLS1,U2AF1L4,BTRC |
| Rap signaling pathway | F2R,SIPA1L2,MAGI2,PFN3,MLLT4,RAPGEF1,PDGFB,SIPA1L1,FGF5,ITGAM |
Protein Function
PFN2 has several biochemical functions, for example, actin monomer binding,adenyl-nucleotide exchange factor activity,phosphatidylinositol-4,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFN2 itself. We selected most functions PFN2 had, and list some proteins which have the same functions with PFN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| adenyl-nucleotide exchange factor activity | GRPEL2,SIL1,HSPBP1,PFN1,GRPEL1 |
| actin monomer binding | MYL2,TWF1,PRKCE,LMOD3,MKL1,COBLL1,NOS3,TMSB,TWF2,PFN4 |
| phosphatidylinositol-4,5-bisphosphate binding | TWF1,SNX20,KRIT1,STXBP6,FCHO2,SESTD1,SNX21,ALOX15,SYTL2,RPH3A |
| protein binding | ZFP64,ECM1,C22orf29,KIR2DL1,STAM2,TOMM34,ANKRD10,APOO,CCDC116,BAD |
Interacting Protein
PFN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PFN2.
Wasl;HTT;GOLGB1;EPB41;HLA-B;VHL;WASF1;PRKAB1;TRAF6;SGTA;NDUFB8;DLST;RPS10;RAP1GAP
Resources
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References
- Mas, S; Garrido-Arandia, M; et al. Characterization of Profilin and Polcalcin Panallergens From Ash Pollen. JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY 24:257-266(2014).
- Ribeiro, H; Morales, S; et al. Analysis of the pollen allergen content of twelve olive cultivars grown in Portugal. AEROBIOLOGIA 29:513-521(2013).
