PAX8
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Official Full Name
paired box 8 -
Overview
This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family;typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This;nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations;in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular;thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
PAX8;paired box 8;paired box gene 8;paired box protein Pax-8;paired domain gene 8
Recombinant Proteins
- Mouse
- Human
- Rat
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- His
- Non
- Myc&DDK
- His&Fc&Avi
- His&Myc
- Flag
Involved Pathway
PAX8 involved in several pathways and played different roles in them. We selected most pathways PAX8 participated on our site, such as Thyroid hormone synthesis,Pathways in cancer,Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAX8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | TFG,ITGB1,ZBTB16,GNG7,ARNT,FGF1,WNT9B,MSH6,GNAQ,TRAF5 |
| Thyroid cancer | TFG,HRAS,TPR,RXRG,MAP2K2,RXRB,TRP53,RET,TCF7L2,CDH1 |
| Transcriptional misregulation in cancer | IL1R2,LYL1,HDAC1,Aff1,PML,NR4A3,HIST1H3C,HIST1H3A,TP53,GOLPH3 |
| Thyroid hormone synthesis | GPX7,CREB5,HSPA5,PRKCA,ATP1A3,ATP1B1,PLCB4,GPX3,PRKCB,PRKACB |
Protein Function
PAX8 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAX8 itself. We selected most functions PAX8 had, and list some proteins which have the same functions with PAX8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | RBPJ,ONECUT2,POU4F2,OTX1,NFYC,HOXC13,EHF,MAFB,NFIB,SPI1 |
| protein binding | TFDP2,PLXNB2,C1orf21,YWHAH,SMAD3,KCND2,ZNF436,Icosl,ACTN1,C3 |
| DNA binding | HMGN1,ZNF701,HNF1A,FBXL19,ZBTB3,PAX6B,CSDC2A,ZNF496,TRIM27,HELZ2 |
| thyroid-stimulating hormone receptor activity | TSHR |
| transcription regulatory region DNA binding | H2AFY2,GFI1,KDM1A,ZFP821,SREBF1,TBP,NCOR1,WNT5A,HINFP,SERPINB1A |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | POU4F3,POU2F2,MIXL1,TFAM,NR1H2,MITFA,MYF5,GLI3,RBPJ,ZKSCAN3 |
| transcription factor activity, sequence-specific DNA binding | ZNF624,ZNF12,TFCP2L1,YEATS4,HSF5,POU3F2,TAF5L,INSM1B,HOXC6B,ATF6B |
| RNA polymerase II core promoter sequence-specific DNA binding | RUVBL2,STAT5A,PAX6,TBR1,GATA3,SMAD1,SMYD3,SOX8,RBPJ,HNF4A |
Interacting Protein
PAX8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAX8 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAX8.
SERINC1;CLSTN1;RPLP2;RB1;HSPA1A;NCL;ANXA7;RSBN1;TMA16;UNK;CHUK;PKM;CXCL9;e2f1_human_gene
Resources
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References
- Conant, J; DeSarno, M; et al. Positive PAX8 Staining In Lymphoid Neoplasms Depends on Target of Antibody. MODERN PATHOLOGY 28:498A-498A(2015).
- Conant, J; DeSarno, M; et al. Positive PAX8 Staining In Lymphoid Neoplasms Depends on Target of Antibody. LABORATORY INVESTIGATION 95:498A-498A(2015).
