NOS3
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Official Full Name
nitric oxide synthase 3 -
Overview
Endothelial NOS (eNOS), also known as nitric oxide synthase 3 (NOS3) or constitutive NOS (cNOS), is an enzyme that in humans is encoded by the NOS3 gene. Endothelial NOS is a nitric oxide synthase that generates NO in blood vessels and is involved with regulating vascular tone by inhibiting smooth muscle contraction and platelet aggregation. A constitutive Ca2+ dependent NOS provides a basal release of NO. eNOS is associated with plasma membranes surrounding cells and the membranes of Golgi bodies within cells. -
Synonyms
NOS3;Nitric oxide synthase 3 (endothelial cell);eNOS;ECNOS;Constitutive NOS;Endothelial NOS;EC-NOS;NOSIII;cNOS;NOS type III;EC 1.14.13.39;nitric oxide synthase, endothelial;OTTHUMP00000213183;OTTHUMP00000212826;OTTHUMP00000213184;OTTHUMP00000213185
Recombinant Proteins
- Mouse
- Human
- Rat
- Cattle
- Dog
- Pig
- Bovine
- Mammalian Cells
- Wheat Germ
- Sf9 Cells
- E.coli
- HEK293
- Insect Cells
- His
- Non
- T7
- DDK
- Myc
- Avi
- Fc
- Flag
- GST
Involved Pathway
NOS3 involved in several pathways and played different roles in them. We selected most pathways NOS3 participated on our site, such as Arginine biosynthesis,Arginine and proline metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Estrogen signaling pathway | ATF4,SP1,PIK3CB,SHC4,PRKACG,FKBP4,CALM3,CALM1,MMP2,PLCB2 |
| Insulin resistance | PRKAA1,G6PC2,G6PC3,PPP2R4,NFKBIAB,PIK3CB,SOCS3,RPS6KA3B,AKT2L,AKT1 |
| VEGF signaling pathway | PTK2,PLCG2,HRAS,PTGS2A,MAPK12B,PLA2G4F,MAPK1,VEGFAA,MAPK13,HRASB |
| Calcium signaling pathway | HTR2A,TACR3L,PPP3CCA,PDGFRB,PLCB2,BDKRB1,DRD1,AGTR1,CAMK2D2,GNA14 |
| PIK-Akt signaling pathway | CCND1,PIK3CD,FGFR1,SYK,TNN,IGF1,LPAR4,SPP1,IL2RA,RELA |
| HIF- signaling pathway | TCEB1,TFRC,HMOX1,MKNK1,PIK3R5,GM5506,SERPINE1,HK3,GAPDH,RELA |
| Arginine biosynthesis | ARG2,NOS2,GOT2A,ASL,NOS2A,GLULB,GLS2,ybaS,GLULC,ACY1 |
| Platelet activation | PRKG1,ROCK2,GP5,MAPK1,LYN,SYK,PLA2G4F,F2R,AKT2,ARHGEF12 |
| cGMP-PKG signaling pathway | INS2,INS1,PPP1CC,SLC25A31,SLC25A5,MAPK3,NFATC2,GUCY1B3,SLC25A4,GATA4 |
Protein Function
NOS3 has several biochemical functions, for example, FMN binding,NADP binding,NADPH-hemoprotein reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NOS3 itself. We selected most functions NOS3 had, and list some proteins which have the same functions with NOS3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADPH-hemoprotein reductase activity | NOS1,NOS2,NDOR1,NOS2B,POR,MTRR,CYP2J6,NOS2A |
| cadmium ion binding | MT3,SLC11A2,P2RX2,NOS1 |
| scaffold protein binding | NOS1,CACNA1G,KRT8,MAPK3,TREM2,ADCY6,NLGN4Y,PDE4D,CAV2,GRIN2A |
| FMN binding | CREG1,POR,NOS1,NDOR1,TYW1,NOS2B,CREG2,HAO1,TYW1B,NOS2A |
| calmodulin binding | SNTB1,MYO5B,DCX,C2orf62,SPTAN1,PLA2G6,CAMK1G,CALD1,AEBP1,CDK5RAP2 |
| protein binding | PNMA2,SAC3D1,ALPP,RBM25,TBC1D5,CCDC12,PRKRIP1,SGIP1,TREML1,IRF4 |
| flavin adenine dinucleotide binding | GFER,XDH,KDM1A,GSR,ACAD8,KMO,TXNRD2,SDHA,D2HGDH,ACADSB |
| iron ion binding | CYP3C1L2,CYP11A1,CYP51A1,CYP11B1,C14orf169,CYP2K17,ISCU,CYP2K22,HBE1,CYP4A11 |
| NADP binding | MTHFR,NOX1,CAT,NOX5,NDOR1,MIOX,GSR,FMO2,PGD,POR |
Interacting Protein
NOS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOS3.
NOSTRIN;AKT1;CDC37;tax;MAGEA11
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References
- Piccoli, JCE; Manfredini, V; et al. Association between endothelial nitric oxide synthase gene polymorphism (-786T > C) and interleukin-6 in acute coronary syndrome. HUMAN & EXPERIMENTAL TOXICOLOGY 33:396-402(2014).
- Syeda, F; Hauton, D; et al. How ubiquitous is endothelial NOS?. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY 166:207-214(2013).
