MDK
-
Official Full Name
midkine -
Overview
This gene encodes a secreted growth factor that belongs to the pleiotrophin/midkine heparin-binding protein family and functions in a variety of biological processes. The encoded cytokine promotes the growth, differentiation, survival and migration of several target cells including leucocytes involved in inflammation. This protein plays a role in the formation of scar tissue and intraperitoneal adhesions, and promotes neurite outgrowth and neuron survival. The protein encoded by this gene is associated with obesity and inhibition of insulin signaling in fat cells. A pseudogene of this gene is present on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] -
Synonyms
MDK;midkine;MK;Mek;retinoic acid-responsive protein;retinoic acid-induced differentiation factor
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cell
- Human
- Insect Cells
- Insect Cell
- HEK293
- Mammalian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- Non
- His&S
- His
- His&Avi
- Flag
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
MDK involved in several pathways and played different roles in them. We selected most pathways MDK participated on our site, such as Glypican 2 network,NOTCH2 Activation and Transmission of Signal to the Nucleus,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MDK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by NOTCH2 | MDKB,MDKA |
| Syndecan-4-mediated signaling events | ADAM12,GIPC1 |
| Signal Transduction | TAS2R3,NTS,ARHGAP40,OR7D2,METAP1,ARHGAP17B,SPOP,CDC42EP3,VIP,ZNRF3 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | MDKA,MIB1,CNTN1,MDKB |
| Signaling by NOTCH | MDKB,DNER,DTX2,TLE4,MDKA,HEYL,TLE2,RAB6A,TLE3,DLK1 |
Protein Function
MDK has several biochemical functions, for example, growth factor activity,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MDK itself. We selected most functions MDK had, and list some proteins which have the same functions with MDK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | BMP8A,VEGFA,GDF6B,IGF2,BMP15,FGF18,NRTN,NTF4,CSF1,TYMP |
| heparin binding | NRP1,FMODA,BMP4,PLA2G2D,SELP,LIPC,KNG1,UBE4A,RSPO4,CCL8 |
Interacting Protein
MDK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MDK here. Most of them are supplied by our site. Hope this information will be useful for your research of MDK.
UBQLN4;SRPK2;RPL18A;MAPK6
Resources
Related Services
Related Products
References
- Hugosson, F; Sjogren, C; et al. The Drosophila Midkine/Pleiotrophin Homologues Miple1 and Miple2 Affect Adult Lifespan but Are Dispensable for Alk Signaling during Embryonic Gut Formation. PLOS ONE 9:-(2014).
- Kojima, H; Kosugi, T; et al. Deficiency of Growth Factor Midkine Exacerbates Necrotizing Glomerular Injuries in Progressive Glomerulonephritis. AMERICAN JOURNAL OF PATHOLOGY 182:410-419(2013).
