MDH1
-
Official Full Name
malate dehydrogenase 1, NAD (soluble) -
Overview
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. -
Synonyms
MDH1;malate dehydrogenase 1, NAD (soluble);malate dehydrogenase, cytoplasmic;Cytosolic malate dehydrogenase;MDHA;MDHs;Soluble malate dehydrogenase;MOR2;MDH-s;MGC:1375
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- Bovine
- E.coli
- Chicken
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Avi
- Fc
- GST
- Flag
- DDK
- Myc
Involved Pathway
MDH1 involved in several pathways and played different roles in them. We selected most pathways MDH1 participated on our site, such as Citrate cycle (TCA cycle),Cysteine and methionine metabolism,Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MDH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proximal tubule bicarbonate reclamation | GLS2,FXYD2,CA2,ATP1A2,AQP1,Car4,SLC4A4,ATP1B4,ATP1B3,ATP1B2 |
| Citrate cycle (TCA cycle) | DLD,MDH2,ACO1,CS,PCK2,IDH2,PDHA1B,SDHA,SDHD,OGDHL |
| Metabolic pathways | MAT1A,AHCYL2,CYP2C70,ASNS,ALOX12,COASY,KMO,ACSS2L,GOT1,ATP6V1G1 |
| Glyoxylate and dicarboxylate metabolism | HAO2,GLDC,PCCA,GCSHB,PGP,CAT,AGXT,HAO1,ACO1,AMT |
| Pyruvate metabolism | SLC16A8,ALDH3A2,ACACA,PDPR,hchA,PDP2,PC,ACYP2,ME2,GLO1 |
| Carbon metabolism | HAO1,SDHDA,ENO1,PGP,PKM2,PKM,PGAM2,MTHFR,PDHA1,FBP2 |
| Cysteine and methionine metabolism | LDHAL6A,AHCYL1,LDHBA,MAT2AB,GCLC,CDO1,MAT2B,CTH,SMS,MAT2AL |
Protein Function
MDH1 has several biochemical functions, for example, L-malate dehydrogenase activity,NAD binding,diiodophenylpyruvate reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MDH1 itself. We selected most functions MDH1 had, and list some proteins which have the same functions with MDH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| L-malate dehydrogenase activity | MDH2,MDH1AA |
| protein binding | FH,BIN1,GLRB,SNIP1,TUBA1C,THOC4,CCDC153,ZNHIT6,ASB7,KHDC1B |
| malic enzyme activity | ME3,ME1,ME2 |
| NAD binding | ME3,GAPDHS,CYB5R3,HADHA,HSD3B5,IDH1,NDUFV1,IDH2,PHGDH,CTBP1 |
Interacting Protein
MDH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MDH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MDH1.
TERF1;EGFR;FUS;MPP3;TERF2IP;HSP90AB1;IQCB1;ATG5
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