Active Recombinant Rabbit LDLR protein, Fc-tagged

• Cat.No.: LDLR-0328R
• Product Overview: Recombinant Rabbit LDLR protein(Ala9-Gly765), fused with Fc tag, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Rabbit
• Tag: Fc
• Form: Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.
• Bio-activity: Immobilized Human PCSK9 Propeptide & Rabbit Mature PCSK9 (154-686), His Tag at 2 μg/mL (100 μL/well) can bind Rabbit LDL R, Fc Tag with a linear range of 2-78 ng/mL.
• Molecular Mass: This protein carries a human IgG1 Fc tag at the C-terminusThe protein has a calculated MW of 109.2 kDa. The protein migrates as 120-140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Proteinlength: Ala9-Gly765
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >90% as determined by SDS-PAGE.
• Storage: For long term, the product should be stored at lyophilized state at -20°C or lower.Please avoid repeated freeze-thaw cycles. This product is stable after at:
  -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
• Protein length: Ala9-Gly765

Gene Information

• Gene Name: LDLR low density lipoprotein receptor [ Oryctolagus cuniculus ]
• Official Symbol: LDLR
• Synonyms: LDLR; low density lipoprotein receptor
• Gene ID: 100009086

Reviews

08/11/2020

The LDLR protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

10/07/2018

Its purity and consistency guarantee reliable and reproducible results, ensuring the reliability of my research outcomes.

03/04/2017

the LDLR protein offers superior quality and reliability, making it a perfect fit for my experimental needs.

Q&As

Are there conditions where upregulation of LDLR might be beneficial?

Yes, conditions where increasing the expression or function of LDLR could potentially aid in reducing circulating LDL cholesterol and minimizing cardiovascular risk.

Are there ongoing research efforts regarding LDLR and its clinical applications?

Yes, research is continually conducted to better understand LDLR-related conditions and to develop more effective treatments, including gene-editing technologies and novel therapies.

What are the clinical implications of LDLR dysfunction?

Dysfunction in LDLR can lead to high levels of LDL cholesterol in the blood, contributing to conditions like familial hypercholesterolemia and an increased risk of heart disease.

How does LDLR impact atherosclerosis?

A dysfunctional LDLR can lead to an accumulation of LDL cholesterol in the arteries, promoting atherosclerosis, the hardening and narrowing of arteries.

What treatment options exist for LDLR-related conditions?

Treatments involve lifestyle changes, cholesterol-lowering medications, and in some cases, gene therapies or specialized medications targeting the LDL receptor.