KLK7
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Official Full Name
kallikrein-related peptidase 7 -
Overview
This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011] -
Synonyms
KLK7;kallikrein-related peptidase 7;hK7;SCCE;PRSS6;kallikrein-7;signal protein;serine protease 6;stratum corneum chymotryptic enzyme;kallikrein 7 (chymotryptic, stratum corneum)
Recombinant Proteins
- Human
- Mouse
- Rat
- HEK293
- Human
- E.coli
- Wheat Germ
- Human Cell
- Mammalian cells
- HEK293T
- Yeast
- In Vitro Cell Free System
- His
- Non
- His&GST
- GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
KLK7 involved in several pathways and played different roles in them. We selected most pathways KLK7 participated on our site, such as Degradation of the extracellular matrix,Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Degradation of the extracellular matrix | CTSK,TPSAB1,COL25A1,ADAM8A,CTRB1,COL15A1B,COL9A1,ADAMTS5,COL19A1,CTSLL |
| Extracellular matrix organization | NID2,LTBP3,LOC100686744,TIMP2B,COL5A3A,EMID2,TLL1,ADAM15,COL4A3,LEPRE1 |
Protein Function
KLK7 has several biochemical functions, for example, peptidase activity,serine-type endopeptidase activity,serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLK7 itself. We selected most functions KLK7 had, and list some proteins which have the same functions with KLK7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type peptidase activity | PRTN3,TMPRSS4A,PRSS21,PRSS40,DPP4,PRSS59.2,DPP7,MCPT8,SEC11C,Gzmg |
| peptidase activity | HM13,MMP30,ELA2L,Ren1,MMP25,MPND,THSD4,MCPT2,NAPSA,FAM105B |
| serine-type endopeptidase activity | GZMM,TPP2,F7I,PRSS39,PRSS8,PRSS42,C1rb,PRSS28,PRSS1,CTSC |
Interacting Protein
KLK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLK7.
BAG4;CHEK2;TGFB1;PTPN1;WT1;CCND1;PTPRJ;STK11
Resources
Research Area
Serine Proteases and RegulatorsFibrinolysis System
Plasmin/Plasminogen and Kallikrein/Kinin Systems
Related Services
Related Products
References
- Yamamuro, T; Hori, M; et al. Tickling stimulation causes the up-regulation of the kallikrein family in the submandibular gland of the rat. BEHAVIOURAL BRAIN RESEARCH 236:236-243(2013).
- Yamamoto, M; Miyai, M; et al. Kallikrein-related Peptidase-7 Regulates Caspase-14 Maturation during Keratinocyte Terminal Differentiation by Generating an Intermediate Form. JOURNAL OF BIOLOGICAL CHEMISTRY 287:32825-32834(2012).
