KDM4A
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Official Full Name
lysine (K)-specific demethylase 4A -
Overview
The methylation state of lysine residues in histone proteins is a major determinant of the formation of active and inactive regions of the genome and is crucial for proper programming of the genome during development (1,2). Jumonji C (JmjC) domain-contain -
Synonyms
KDM4A;lysine (K)-specific demethylase 4A;JMJD2, JMJD2A, jumonji domain containing 2 , jumonji domain containing 2A;lysine-specific demethylase 4A;JHDM3A;jumonji C domain containing histone demethylase 3A;KIAA0677;jumonji domain containing 2;jumo
Recombinant Proteins
- Human
- Mouse
- E.coli
- Sf9 Cells
- HEK293
- Insect Cells
- Mammalian Cells
- His
- Flag
- GST
- Myc&DDK
- StrepII
- Non
- His&Fc&Avi
Involved Pathway
KDM4A involved in several pathways and played different roles in them. We selected most pathways KDM4A participated on our site, such as Chromatin modifying enzymes,Chromatin organization,DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | EYA3,KDM4B,EYA4,BAZ1B,EYA2 |
| Chromatin organization | AEBP2,SMARCD1,C20orf20,EPC1,PHF21A,CARM1,PBRM1L,PAX3A,COPRS,ELP3 |
| Chromatin modifying enzymes | RUVBL2,KAT5,DPY30,MSL2A,KDM2AA,PADI2,WDR77,SAP18,CARM1,KDM2A |
| DNA Double-Strand Break Repair | RAD50,BARD1,TDP2,EYA2,PARP2,BAZ1B,KDM4B,POLD3,CHEK2,EME1 |
| HDMs demethylate histones | KDM5A,ARID5B,KDM3B,KDM7AB,KDM5BB,JHDM1D,PHF8,KDM4B,KDM6B,KDM4D |
| DNA Double Strand Break Response | FAM175A,EYA4,BABAM1,RNF168,HTATIP,TP53BP1,EYA3,BAZ1B,BARD1,SMARCA5 |
| DNA Repair | RNF111,RAD51AP1,RAD9,TDP2,ZNF830,GPS1,COPS7A,RNF168,GEN1,COPS3 |
Protein Function
KDM4A has several biochemical functions, for example, histone demethylase activity (H3-K36 specific),methylated histone binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM4A itself. We selected most functions KDM4A had, and list some proteins which have the same functions with KDM4A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone demethylase activity (H3-K36 specific) | PHF8,C14orf169,JHDM1D,KDM8,JMJD5,KDM2A,KDM2B |
| protein binding | THRAA,BAZ1A,NANOS3,BPIFA2,ZNF707,EYA1,CSTF2T,DCP1B,EPRS,EEF2 |
| methylated histone binding | PHF1,KAT8,MSL3,SPIN1,CBX4,RRP8,MPHOSPH8,ATRX,FAM156A,ING1 |
| ubiquitin protein ligase binding | DAXX,PRKAR2B,MAP1LC3B,USP25,UBE2V1,MFN2,CUL1,PA2G4,ANAPC2,UBE2G2 |
| zinc ion binding | ZCCHC2,APOBEC2B,TRIM2A,TRIM69,LHX3,TXNDC17,FHL2,KNG1,ADAM7,LHX8 |
Interacting Protein
KDM4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM4A here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM4A.
HIST2H4B;HIST1H3D;HIST3H3
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References
- Chin, YW; Han, SY; et al. KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review. EXPERT OPINION ON THERAPEUTIC PATENTS 25:135-144(2015).
- Sowalsky, AG; Xia, Z; et al. Whole Transcriptome Sequencing Reveals Extensive Unspliced mRNA in Metastatic Castration-Resistant Prostate Cancer. MOLECULAR CANCER RESEARCH 13:98-106(2015).
