Recombinant Human KDM4A Protein, Strep II-tagged

• Cat.No.: KDM4A-010H
• Product Overview: Recombinant Human KDM4A protein (2-350) with a N-terminal Strep II-tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: StrepII
• ProteinLength: 2-350
• Description: This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.
• Molecular Mass: 42.7 kDa
• Purity: ≥95% estimated by SDS-PAGE
• Unit Definition: One unit is defined as the amount of enzyme required to produce 1 nmol of NADH per minute at 37 centigrade in 50 mM HEPES buffer, pH 7.4, containing 50 mM sodium chloride, 1 mM ascorbic acid, 50 μM ferrous ammonium sulfate, 1 mM NAD + , 1 mM α-ketoglutarate, 0.1 μM FDH, and 125 μM H3K9me3 peptide.
• Stability: ≥ 6 months
• Storage: -80 centigrade
• Storage Buffer: 20 mM HEPES, pH 7.4, and 150 mM sodium chloride

Gene Information

• Gene Name: KDM4A lysine demethylase 4A [ Homo sapiens (human) ]
• Official Symbol: KDM4A
• Synonyms: KDM4A; lysine demethylase 4A; JMJD2; JHDM3A; JMJD2A; TDRD14A; lysine-specific demethylase 4A; [histone H3]-trimethyl-L-lysine(36) demethylase 4A; [histone H3]-trimethyl-L-lysine(9) demethylase 4A; jmjC domain-containing histone demethylation protein 3A; jumonji C domain-containing histone demethylase 3A; jumonji domain containing 2; jumonji domain containing 2A; jumonji domain-containing protein 2A; lysine (K)-specific demethylase 4A; tudor domain containing 14A; EC 1.14.11.66; EC 1.14.11.69
• Gene ID: 9682
• mRNA Refseq: NM_014663
• Protein Refseq: NP_055478
• MIM: 609764
• UniProt ID: O75164