Ifna1
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Official Full Name
interferon, alpha 1 -
Overview
The protein encoded by this gene is produced by macrophages and has antiviral activity. This gene is intronless and the encoded protein is secreted. -
Synonyms
IFNA1;IFL;IFN;IFNA@;IFNA13;IFN-ALPHA;IFN-alphaD;interferon alpha-1/13;leIF D;IFN-alpha 1b;IFN-alpha-1/13;interferon-alpha1;interferon alpha-D;interferon alpha 1b;IFNA1;interferon, alpha 1
Recombinant Proteins
- Human
- Rat
- Mouse
- Equine
- Pig
- Cattle
- Dog
- Chicken
- Guinea pig
- Sheep
- Porcine
- Bovine
- Horse
- E.coli
- HEK293
- Yeast
- Mammalian Cell
- Insect Cell
- Human Cell
- CHO
- HEK293F
- Sf9 Insect Cell
- Mammalian cells
- HEK293T
- GST
- Fc
- Non
- His
- StrepII
- His&T7
- His&GST
- His&Flag
- His&Fc&Avi
- Myc&DDK
- Flag
- His&SUMO
- N-His&C-Myc
Involved Pathway
Ifna1 involved in several pathways and played different roles in them. We selected most pathways Ifna1 participated on our site, such as Cytokine-cytokine receptor interaction,Regulation of autophagy,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ifna1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RIG-I-like receptor signaling pathway | NFKBIAB,NLRX1,MAPK8A,MAPK12B,IFNA17,DHX58,IL8L1,IFNA14,IFNK,CXCL8B.3 |
| Natural killer cell mediated cytotoxicity | RAC2,ITGB2,PLCG1,MICB,ZAP70,PIK3CG,TNFRSF10B,PRKCG,BID,KIR2DS5 |
| Tuberculosis | RHOA,RAB7A,Il23a,IFNA13,CAMK2D,HSPD1,cgr2b,HLA-DRB3,BAX,TLR2 |
| Herpes simplex infection | IFNAR2,IFNG,TRP53,SOCS3B,EIF2AK1,BMA2,SRSF2A,SRSF7B,IFNA10,SRSF7 |
| Regulation of autophagy | ATG7,INS1,IFNA14,IFNA8,IFNG1-2,GABARAPL2,ATG13,ATG4C,Ifna11,BECN1 |
| Measles | TACR1,IL2RG,IRF7,IFNA13,DDX58,EIF2AK3,RAB9A,IFNA10,CCNE1,Cd209g |
| Hepatitis C | EIF2AK3,IFNA10,IKBKE,IFNA6,SCARB1,TBK1,IRF7,OAS3,EIF2AK2,IKBKB |
| Hepatitis B | MAPK8,PIK3CA,IFNA7,IKBKG,DDX58,CREB3L1,PTEN,TLR3,MAVS,NFATC3 |
| Toll-like receptor signaling pathway | IFNA10,TLR3,FOS,MAP2K2A,IFNPHI1,PIK3R2,STAT1,MAP2K2B,MAP2K2,TLR4BB |
Protein Function
Ifna1 has several biochemical functions, for example, cytokine activity,type I interferon receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ifna1 itself. We selected most functions Ifna1 had, and list some proteins which have the same functions with Ifna1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| type I interferon receptor binding | IFNA4,RNF207B,GM13288,GM13287,IFNPHI2,GM13278,Ifnz,GM13279,IFNA7,IFNK |
| cytokine activity | SP100,IL22,Il2,GDF11,AREG,IFNG1-2,LTB,CLCF1,IL28A,TNFSF10 |
Interacting Protein
Ifna1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ifna1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ifna1.
Resources
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References
- Thim, HL; Iliev, DB; et al. Immunoprotective activity of a Salmonid Alphavirus Vaccine: Comparison of the immune responses induced by inactivated whole virus antigen formulations based on CpG class B oligonucleotides and poly I:C alone or combined with an oil adjuvant. VACCINE 30:4828-4834(2012).
- Kennedy, RB; Ovsyannikova, IG; et al. Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes. VACCINE 30:2159-2167(2012).
