HLA-G
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Official Full Name
major histocompatibility complex, class I, G -
Overview
HLA-G is a nonclassical MHC class I (MHC-Ib) molecule structurally related to MHC class Ia (HLA-A,B, C). There are seven isoforms of this molecule, including membrane bound HLA-G1, -G2, -G3 and -G4 and soluble HLA-G5, -G6, and -G7. HLA-G is primarily expr -
Synonyms
HLA-G;major histocompatibility complex, class I, G;HLA G histocompatibility antigen, class I, G;HLA class I histocompatibility antigen, alpha chain G;b2 microglobulin;HLA G antigen;HLA class I molecule;MHC class I antigen G;HLA-G histocompatibility antigen, class I, G;MHC-G
Recombinant Proteins
- Human
- Cynomolgus
- Rhesus macaque
- HEK293
- E.coli
- Wheat Germ
- Mammalian Cells
- Insect cells
- Yeast
- In Vitro Cell Free System
- Avi&His
- B2M&His
- His
- GST
- DDK&Myc
- His&SUMO
- Non
- Avi&Fc&His
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-G-312H |
Recombinant Human HLA-G Protein, His-Avi-tagged
|
HEK293 | Human | Avi&His | It contains Gly25-Thr305 (HLA-G), Ile21-Met119 (B2M) and RIIPRHLQL peptide. | |
| HLA-G-4305H |
Recombinant Human HLA-G protein, His-B2M-tagged
|
E.coli | Human | B2M&His | 25-308aa | |
| HLA-G-1241H | Recombinant Human HLA-G Protein | HEK293 | Human | His | 25-338 a.a. | |
| HLA-G-13828H | Recombinant Human HLA-G, GST-tagged | E.coli | Human | GST | 26-308a.a. | |
| HLA-G-27H | Recombinant Human HLA-G protein, GST-tagged | Wheat Germ | Human | GST | 1-338 a.a. | |
| HLA-G-001H | Active Recombinant Human HLA-G Protein, Myc/DDK-tagged | HEK293 | Human | DDK&Myc | ||
| HLA-G-033H | Recombinant Human HLA-G Protein, His-tagged | E.coli | Human | His | 26-308 aa | |
| HLA-G-39H | Recombinant Human HLA-G protein | E.coli | Human | His&SUMO | 25-338 a.a. | |
| HLA-G-501H |
Active Recombinant Human HLA-G protein, His-Avi-tagged
|
HEK293 | Human | Avi&His | It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide. |
|
| HLA-G-505HP |
Active Recombinant Human HLA-G complex Protein (tetramer), His-Avi-tagged, PE-Labeled
|
HEK293 | Human | Avi&His | Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide |
|
| HLA-G-26H | Recombinant Human HLA-G protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
|
|
| HLA-G-38H | Recombinant Human HLA-G protein | E.coli | Human | His | 25-338 a.a. |
|
| HLA-G-5493HCL | Recombinant Human HLA 293 Cell Lysate | HEK293 | Human | Non |
|
|
| HLA-G-1077H | Recombinant Human HLA-G Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
|
|
| HLA-G-1077H-B | Recombinant Human HLA-G Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
||
| HLA-G-1718HFL | Recombinant Full Length Human HLA-G Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
|
| HLA-G-2243H | Recombinant Human HLA-G Protein, His-tagged | E.coli | Human | His | Gly25-Ile308 |
|
| HLA-G-2792HFL | Recombinant Full Length Human HLA-G protein, Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
|
| HLA-G-3036H | Recombinant Human HLA-G protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 25-308aa |
|
| HLA-G-3075H | Recombinant Human HLA-G Protein (Met29-His117), N-GST tagged | E.coli | Human | GST | Met29-His117 |
|
| HLA-G-3322H | Recombinant Human HLA-G protein, His-tagged | Insect cells | Human | His | 25-319aa |
|
| HLA-G-502H | Recombinant Human HLA-G protein(Gly25-Thr305(C66S)), His-Avi-tagged | E.coli | Human | Avi&His | Gly25-Thr305(C66S) |
|
| HLA-G-503C | Recombinant Cynomolgus HLA-G protein, His-Avi-tagged | HEK293 | Cynomolgus | Avi&His | Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide |
|
| HLA-G-503CB | Recombinant Cynomolgus HLA-G protein, His-Avi-tagged, Biotinylated | HEK293 | Cynomolgus | Avi&His | Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide |
|
| HLA-G-503H | Recombinant Human HLA-G protein, His-Avi-tagged, Biotinylated | HEK293 | Human | Avi&His | It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide. |
|
| HLA-G-504H | Recombinant Human HLA-G protein, His-Avi-tagged, Biotinylated | HEK293 | Human | Avi&His | It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide. |
|
| HLA-G-505C | Recombinant Cynomolgus HLA-G Tetramer protein, His-Avi-tagged | HEK293 | Cynomolgus | Avi&His | Gly25-Thr305(HLA-G)&Ile21-Met119(B2M) |
|
| HLA-G-506R | Recombinant Rhesus macaque HLA-G protein, His-Avi-tagged | HEK293 | Rhesus macaque | Avi&His | It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide. |
|
| HLA-G-5426H | Recombinant Human HLA-G protein | Yeast | Human | His&SUMO | 25-338 a.a. |
|
| HLA-G-651HF | Recombinant Full Length Human HLA-G Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 338 amino acids |
|
Involved Pathway
HLA-G involved in several pathways and played different roles in them. We selected most pathways HLA-G participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | RRAS2,VAC14,CD3E; CD3D,Pdgfa&Pdgfb,CALR,ANAPC11,PCNA,CCND2,XBP1,FZD7 |
| ne thyroid disease | HLA-DRB3,CD86,IFNA1,HLA-DRB1,HLA-DOB,HLA-B,IFNA21,IFNA16,FAS,CD40 |
| Type I diabetes mellitus | HLA-DRB4,HLA-DMB,CD28,HLA-DRA,GZMB,INS2,PTPRN,GAD1,INS1,HLA-DMA |
| Viral carcinogenesis | MAPKAPK2,YWHAH,SCIN,HLA-A,GTF2H3,RB1,TRAF2,VAC14,HDAC11,HIST2H2BB |
| Epstein-Barr virus infection | IL10RA,YWHAG,TBPL1,TRP53,HLA-E,HLA-DRB5,PSMD7,HSPA6,CD44,PIK3R5 |
| Allograft rejection | HLA-A,FAS,H2-AB1,HLA-DRB1,IL12A,HLA-DRB5,IL5,HLA-DQB1,HLA-F,CD28 |
| Graft-versus-host disease | CD86,IFNG,HLA-DQA2,HLA-DOA,HLA-A,HLA-C,HLA-DMA,HLA-DQA1,HLA-DPA1,FAS |
| Natural killer cell mediated cytotoxicity | GZMB,KLRD1,NCR3,NCR2,IFNA14,RAC1,ULBP2,ZAP70,PRF1,FCGR4 |
| Autoi | PRF1,IFNA10,HLA-DRB5,HLA-DRB3,HLA-DMB,H2-Q10,HLA-A,IFNA1,IL4,Fasl |
Protein Function
HLA-G has several biochemical functions, for example, peptide antigen binding,protein homodimerization activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-G itself. We selected most functions HLA-G had, and list some proteins which have the same functions with HLA-G. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide antigen binding | CLEC4M,HLA-DRB3,HLA-DRB5,HLA-A,HLA-DPA1,HLA-F,MHC1UBA,HLA-DRB4,H2-AA,MHC1ZFA |
| protein homodimerization activity | ENG,EPHX2,UGT1A1,GRPEL1,DAXX,BAXA,HAND1,AP1S2,APOE,TYR |
| receptor binding | WNT5B,CD2,TNFSF4,PLA2G1B,CTNND1,INSL4,FGF18A,AGRP,CAPRIN2,ECI2 |
Interacting Protein
HLA-G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-G here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-G.
LILRB1;HLA-A
Resources
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References
- Han, MY; Jiang, YZ; et al. sHLA-G Involved in the Apoptosis of Decidual Natural Killer Cells Following Toxoplasma gondii Infection. INFLAMMATION 37:1718-1727(2014).
- Brugiere, O; Thabut, G; et al. Role of HLA-G as a Predictive Marker of Low Risk of Chronic Rejection in Lung Transplant Recipients: A Clinical Prospective Study. AMERICAN JOURNAL OF TRANSPLANTATION 15:461-471(2015).
