FCER2
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Official Full Name
Fc fragment of IgE, low affinity II, receptor for (CD23) -
Overview
CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets. There are two forms of CD23: CD23a and CD23b. CD23a is present on follicular B cells, whereas CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhans cells, eosinophils, and macrophages. -
Synonyms
CD23;FCE2;CD23A;IGEBF;CLEC4J;low affinity immunoglobulin epsilon Fc receptor;BLAST-2;CD23 antigen;fc-epsilon-RII;lymphocyte IgE receptor;immunoglobulin E-binding factor;C-type lectin domain family 4, member J
Recombinant Proteins
- Human
- Rat
- Mus musculus
- HEK293
- Human Cells
- E.coli
- Sf9 Cells
- Wheat Germ
- Human
- Mammalian Cells
- In Vitro Cell Free System
- Avi&His
- Fc
- Strep II
- Non
- GST
- Flag
- His
- His&SUMO
Involved Pathway
FCER2 involved in several pathways and played different roles in them. We selected most pathways FCER2 participated on our site, such as Hematopoietic cell lineage,Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCER2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hematopoietic cell lineage | FCGR1A,DNTT,IL2RA,HLA-DRB3,IL1R1,THPO,Kitl,GM13305,CD1C,CD22 |
| Epstein-Barr virus infection | POLR2D,NFKBIE,POLR2H,PIK3CD,PSMD12,EIF2AK2,IL10RA,SND1,TNFAIP3,HLA-E |
Protein Function
FCER2 has several biochemical functions, for example, IgE binding,carbohydrate binding,integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCER2 itself. We selected most functions FCER2 had, and list some proteins which have the same functions with FCER2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| integrin binding | ADAM23,FN1,THBS1,PXN,JAM3,ICAM4,ACTN4,THBS4,CALR,VWF |
| IgE binding | LGALS3,Fcer2a,FCER1A,CD247L,FCER1G,MS4A2 |
| carbohydrate binding | GALNT4,CD209B,SFTPD,Fcer2a,GFPT1,REG1A,Cd24a,CD55,EMC7,LGALSLA |
| metal ion binding | NUDT10,ZFP354A,HPD,PPTC7,ZFP354C,FGD5,PPP6C,MCCC1,ZNF580,SP1 |
| protein binding | EIF5A2,CASR,TTC5,GHITM,TMEM106C,SOCS7,FAM19A1,TRAF3IP2,FOXRED2,PCGF2 |
Interacting Protein
FCER2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCER2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FCER2.
ATF7
Resources
Research Area
Fc ReceptorsITIM/ITAM Immunoreceptors and Related Molecules
B Cell CD Antigen
Eosinophils
B Cell Markers
CD Antigen (Eosinophils)
MDSC Phenotyping - Negative Markers
C-type Lectin Family
Related Services
Related Products
References
- Rogers, AJ; Tantisira, KG; et al. Predictors of poor response during asthma therapy differ with definition of outcome. PHARMACOGENOMICS 10:1231-1242(2009).
- Tantisira, K; et al. Genetic variation in FCER2: implications for children with asthma. PHARMACOGENOMICS 9:805-807(2008).
