Recombinant Human Fc Fragment Of IgE, Low Affinity II, Receptor For (CD23)

• Cat.No.: FCER2-4979H
• Product Overview: Recombinant humanFCER2 protein, was expressed in E. coli and purified by using conventionalchromatography techniques.

Specification

• Cat. No.: FCER2-4979H
• Description: FCER2, the lowaffinity receptor for IgE, belongs to the C-type lectin structural family andplays a role in the regulation of IgE synthesis and IgE mediated activities.It is found both as a transmembrane receptor protein and in a soluble form,which is generated by proteolytic cleavage of membrane bound FCER2. Thepredominant soluble form of FCER2 (sCD23) consists of 172 amino acidscorresponding to the extracellular domain of the full length precursor.sCD23, in addition to binding IgE, also exerts a number of IgE independentactivities, such as promoting the activation and differentiation of B-cellsand stimulating the release of pro-inflammatory cytokines from monocytes.
• Source: Human
• Host: E. coli
• Form: Supplied as alyophilized powder.
• Purity: > 96% pure bySDS-PAGE and HPLC
• Sequence: Region of FCER2protein corresponding to amino acids MELQVSSGFV CNTCPEKWIN FQRKCYYFGKGTKQWVHARY ACDDMEGQLV SIHSPEEQDF LTKHASHTGS WIGLRNLDLK GEFIWVDGSH VDYSNWAPGEPTSRSQGEDC VMMRGSGRWN DAFCDRKLGA WVCDRLATCT PPASEGSAES MGPDSRPDPD GRLPTPSAPLHS.
• Molecular Mass: 19.2 kDa
• Applications: Numerousapplications are possible with this product and should be tested by the enduser under their own laboratory conditions.
• Storage: Store at 4 deg Cuntil reconstitution. Following reconstitution aliquot and freeze at -20 degC for long term storage. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: FCER2
• Tag: Non

Gene Information

• Gene Name: FCER2 Fc fragment of IgE, low affinity II,receptor for (CD23) [ Homo sapiens ]
• Synonyms: FCER2; Fc fragmentof IgE, low affinity II, receptor for (CD23); Immunoglobulin E-bindingfactor; Lymphocyte IgE receptor; BLAST-2; C-type lectin domain family 4member J; CD23 antigen; Fc fragment of IgE, low affinity II, receptor for(CD23A); C-type lectin domain family 4, member J; fc-epsilon-RII; lowaffinity immunoglobulin epsilon Fc receptor; Fc-epsilon-RII; CD23; CD23A;IGEBF; CLEC4J; FCE2
• Gene ID: 2208
• mRNA Refseq: NM_001207019
• Protein Refseq: NP_001193948
• MIM: 608351
• UniProt ID: P06734
• Chromosome Location: 19p13.3
• Pathway: Hematopoietic celllineage; Hematopoietic cell lineage; IL4-mediated signaling events; IL-3Signaling Pathway
• Function: IgE binding;integrin binding; metal ion binding; receptor activity; sugar binding;binding