Ctsz
-
Official Full Name
cathepsin Z -
Overview
The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. -
Synonyms
CTSZ;cathepsin Z;Cathepsin P;Cathepsin X;Cathepsin X precursor;Cathepsin Z precursor;CathepsinP;CathepsinX;CathepsinZ;CATZ_HUMAN;CTSX;FLJ17088;Preprocathepsin P;PreprocathepsinP;OTTHUMP00000031409
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- Insect Cells
- HEK293
- Mammalian Cells
- Wheat Germ
- E.coli
- Human Cells
- In Vitro Cell Free System
- His
- GST
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
- N-His-SUMO
Involved Pathway
Ctsz involved in several pathways and played different roles in them. We selected most pathways Ctsz participated on our site, such as Asparagine N-linked glycosylation,COPII (Coat Protein 2) Mediated Vesicle Transport,Cargo concentration in the ER, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ctsz were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| COPII (Coat Protein 2) Mediated Vesicle Transport | NAPG,TRAPPC5,TMED10,BET1,PPP6C,YKT6,CTSC,SEC22C,TRAPPC1,USO1 |
| Lysosome Vesicle Biogenesis | BLOC1S1,CLVS2,AP1S3A,DNASE2,CLVS1,AP4B1 |
| ER to Golgi Anterograde Transport | MIA3,TFG,PPP6R1,PREB,NAPB,ANKRD28,TRAPPC2,BET1,NSFB,CNIH2 |
| Clathrin derived vesicle budding | CNO,AP3S1,BLOC1S1,BLOC1S6,PICALMB,AP1S1,TCEAL4,FTH1A,NAPAA,SNX9 |
| Membrane Trafficking | TFG,NAPB,NAPG,NSFB,GJD3,TRAPPC1,TBC1D8B,CNIH3,TMED2,PICALM |
| Cargo concentration in the ER | SEC24A,CTSC,MCFD2,CNIH3,SERPINA1L,LMAN2,MIA3,CNIH2,SEC23A,LMAN2L |
| Lysosome | MCOLN1,ACP5,CTSC,SMPD1,SUMF1,GAA,NEU1,HYAL1,SLC11A2,ATP6V0A1A |
| Asparagine N-linked glycosylation | GOLGA2,ST8SIA3,PPP6R1,PPP6R3,PPP6C,TRAPPC6B,SLC35A1,DPAGT1,ALG14,ST8SIA2 |
Protein Function
Ctsz has several biochemical functions, for example, cysteine-type endopeptidase activity,cysteine-type peptidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ctsz itself. We selected most functions Ctsz had, and list some proteins which have the same functions with Ctsz. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZFAND6,ELK3,SP1,CCBE1,GATA1,ZNF394,PTH2R,ZFYVE28,HIST1H2BE,BMF |
| cysteine-type peptidase activity | USP27X,SOLH,CASPA,OTULIN,CTSL1,SENP3B,CAPN3,CAPN2A,USP9X,CAPN2L |
| cysteine-type endopeptidase activity | CASP6L1,USP3,CASP6L2,CASP10,USP48,USP18,USP8,ATG4D,CTSBA,USP9X |
Interacting Protein
Ctsz has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ctsz here. Most of them are supplied by our site. Hope this information will be useful for your research of Ctsz.
KRTAP5-9;PLSCR1;MTUS2;KRT40;NOTCH2NL;MID2;Kifc5b
Resources
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References
- Vazquez, R; Astorgues-Xerri, L; et al. Fsn0503h antibody-mediated blockade of cathepsin S as a potential therapeutic strategy for the treatment of solid tumors. BIOCHIMIE 108C:101-107(2015).
- Lee, J; Kim, JH; et al. Novel cathepsin B and cathepsin B-like cysteine protease of Naegleria fowleri excretory-secretory proteins and their biochemical properties. PARASITOLOGY RESEARCH 113:2765-2776(2014).
