Ctsl
-
Official Full Name
cathepsin L -
Overview
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012] -
Synonyms
CTSL;cathepsin L;MEP;CATL;CTSL1;cathepsin L1;major excreted protein;cpl-1;CathePsin L family;CathePsin L family member (cpl-1);cpl 1
Recombinant Proteins
- Human
- Mouse
- Pig
- Rat
- Human Liver
- Mouse
- E.coli
- Mammalian cells
- Wheat Germ
- HEK293
- Insect Cell
- Mammalian Cell
- Human Cell
- HEK293T
- In Vitro Cell Free System
- Non
- His
- GST
- His&GST
- Flag
- His&Fc&Avi
- Myc&DDK
- His&Myc
Involved Pathway
Ctsl involved in several pathways and played different roles in them. We selected most pathways Ctsl participated on our site, such as Lysosome,Phagosome,Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ctsl were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | TLR2-1,CD14,ATP6V1B2,CLEC4M,NCF4,TUBB2A,TUBB2B,BF1,THBS3A,MBL1 |
| Rheumatoid arthritis | TGFB2,IL17A,ATP6V1E2,VEGFA,CCL3,TNFRSF11A,TLR4,IL1B,CD28,ATP6V0E2 |
| Antigen processing and presentation | CTSS,HLA-DMA,HLA-B,HSP90AB1,NFYA,H2-AB1,HLA-DRA,NFYC,PSME2,RFXANK |
| Proteoglycans in cancer | FLNC,ERBB2,NRAS,WNT8B,ITGA2,PXN,STAT3,RRAS,VAV2,HPSE |
| Lysosome | CTSL1B,NAGA,ATP6V0CB,CTSA,ATP6V0A1B,ASAH1,CTSSB.1,HEXA,GLA,AP3M2 |
Protein Function
Ctsl has several biochemical functions, for example, aminopeptidase activity,cysteine-type carboxypeptidase activity,cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ctsl itself. We selected most functions Ctsl had, and list some proteins which have the same functions with Ctsl. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydrolase activity | TIGARB,PLBD2,EIF4A1A,CPD,MTMR1B,Reln,FIGNL1,NT5C3L,MRPL46,USP12A |
| histone binding | H3F3A,CHAF1B,HJURP,HIST2H3C1,CHD2,CTSL1,NOC2L,DAXX,ELP2,UHRF1 |
| peptide binding | CALR,H2-Q10,AVPR2,NPFFR1,CTSL2,GNRHR2,PCSK5,CCKAR,ANPEPB,QRFPR |
| protein binding | DOCK4,CDK5R1,CD27,UNC119B,ASCC1,NCK1,ETS2,SLU7,GP1BB,GOLGA7 |
| cysteine-type endopeptidase activity | USP28,CTSLA,TINAG,UCHL1,USP34,USP24,LGMN,CASP6,FAM49BA,Casp3 |
| cysteine-type carboxypeptidase activity | CTSL2 |
| peptidase activity | CTSB,ST14A,C3orf37,NAALADL1,UFSP2,FURINA,C6AST3,MMP13A,C6AST4,F2RL1.1 |
| aminopeptidase activity | XPNPEP3,ERAP1,PEPD,ERAP2,PHEX,XPNPEP1,RNPEP,XPNPEP2,ANPEP,Npepo |
| cysteine-type peptidase activity | CASP6,CAPN8,CTSK,CAPN12,CTSH,CAPN2A,CTSJ,SENP7B,SENP8,DESI2 |
Interacting Protein
Ctsl has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ctsl here. Most of them are supplied by our site. Hope this information will be useful for your research of Ctsl.
Ctsb;Pi4kb;Serpina3g
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