Recombinant Human CTSL Protein (Thr18-Val333), C-His tagged

• Cat.No.: CTSL-1063H
• Product Overview: Recombinant human CTSL (Thr18-Val333) fused with the C-terminal His tag was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell.
• Source: Mammalian cells
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 39.08 kDa
• Protein length: Thr18-Val333
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles.
  Store at 2 to 8 centigrade for one week.
  Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Lyophilized from PBS, pH 7.4, 1mM EDTA, 4% trehalose, 1% mannitol.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: CTSL cathepsin L [ Homo sapiens (human) ]
• Official Symbol: CTSL
• Synonyms: CTSL; cathepsin L; MEP; CATL; CTSL1; procathepsin L; cathepsin L1; major excreted protein; EC 3.4.22.15
• Gene ID: 1514
• mRNA Refseq: NM_145918
• Protein Refseq: NP_666023
• MIM: 116880
• UniProt ID: P07711