CSK
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- Overview
- Review / Q&A
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Official Full Name
c-src tyrosine kinase -
Overview
Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFKs) by phosphorylation of the SFK carboxy-terminal tyrosine (1,2). Phosphorylated carboxy-terminal tyrosine binds -
Synonyms
CSK;c-src tyrosine kinase;tyrosine-protein kinase CSK;C-Src kinase;protein-tyrosine kinase CYL;MGC117393
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- Chicken
- Sf9 Cells
- E.coli
- Insect Cells
- Mammalian Cells
- Wheat Germ
- HEK293
- Sf21 Cells
- In Vitro Cell Free System
- GST
- Non
- His
- Flag
- Avi
- Fc
- DDK
- Myc
Involved Pathway
CSK involved in several pathways and played different roles in them. We selected most pathways CSK participated on our site, such as ARMS-mediated activation,Adaptive Immune System,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine Signaling in Immune system | NUPL2,IRF9,IFITM3,TRIM3,USP18,LAMTOR2,HLA-DQB2,HERC5,IFIT11,ADAR |
| B Cell Receptor Signaling Pathway | RELA,LCP2A,DOK1B,CD79A,PIK3CA,DUSP4,DOK1,CDK4,IFITM1,PIK3R1 |
| BCR signaling pathway | MALT1,IBTK,MAP4K1,PAG1,NETO2,DOK1,CSNK2A1,POU2F2 |
| CXCR4-mediated signaling events | JAK2,BLK,PAG1,GNB2L1,CFL1,MAPKAP1,ARR3,GNA13,DNM1,CRK |
| ARMS-mediated activation | FGF20A,RASGRP1,FGF8B,LAMTOR2,FGFR1B,DUSP4,PTPRA,PSMD10,PEA15A,FRS3 |
| Costimulation by the CD28 family | CTLA4,MAP3K8,MAPKAP1,THEM4,PDPK1A,HLA-DQB2,BTLA |
| Adaptive Immune System | UBE2F,HLA-DQB2,TRAF7,SIGLEC11,LILRA3,AP2A1,CD200R4,UBE2V1,CTSB,CDKN1A |
| Axon guidance | CSF2RB,EPHB1,SEMA3D,CLTB,CFL2,DPYSL4,KCNQ2,DPYSL2B,MAPK3,FGF20A |
Protein Function
CSK has several biochemical functions, for example, ATP binding,identical protein binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSK itself. We selected most functions CSK had, and list some proteins which have the same functions with CSK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine kinase activity | BAZ1B,KIT,BMX,MAP2K2,EGFR,CAMKK2,SYK,DYRK1B,TYRO3,IGF1R |
| protein phosphatase binding | ITGA1,JUP,MAPK14,ERBB2,PPP6R1,VCAN,ANAPC4,PPP1R3G,PIK3R1,JAK3 |
| protein C-terminus binding | ABL1,CD2AP,CDC20,SHANK3,HSPB7,KPNA3,PDZD11,CITED1,YWHAB,PEX16 |
| protein kinase A catalytic subunit binding | GSK3A,GSK3B,PRKAR1A,PRKAR2B,PJA2,EZR,PKIA,PRKAR2A,SOX9,RYR2 |
| receptor binding | SCYL2,GSTM2,HIST2H3C2,NRG2B,GDNF,HFE2,CXCL1,GFRA3,RARRES2,IDE |
| protein binding | TRAPPC6A,PPARD,BTBD1,CASR,FAM20C,CAPN1,FAM83A,GNA13,SKAP1,HIF1AN |
| ATP binding | BMPR1AB,ATAD1,AURKB,PLK2B,MYHZ1.1,UBA5,ULK2,CHD4A,PFKL,SYN1 |
| non-membrane spanning protein tyrosine kinase activity | SRC,PTK2AB,HCK,LCK,TNK2B,JAK2A,Fert2,TXK,ITK,ZNF143B |
| metal ion binding | ZNF471,RHOU,CYP46A1.2,KCND1,MUTYH,Atp8a2,SMAD4,CHD4A,VPS29,KITA |
Interacting Protein
CSK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSK here. Most of them are supplied by our site. Hope this information will be useful for your research of CSK.
SRC;PTPRC;EGFR;IGF1R;G3BP1
Resources
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References
- Pone, EJ; Lou, Z; et al. B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: Modulation by BCR and CD40, and relevance to T-independent antibody responses. AUTOIMMUNITY 48:1-12(2015).
- Dokmanovic, M; Wu, Y; et al. Trastuzumab-induced recruitment of Csk-homologous kinase (CHK) to ErbB2 receptor is associated with ErbB2-Y1248 phosphorylation and ErbB2 degradation to mediate cell growth inhibition. CANCER BIOLOGY & THERAPY 15:1029-1041(2014).
