Recombinant Human C-src Tyrosine Kinase, GST-tagged, Active

• Cat.No.: CSK-288H
• Product Overview: Recombinant full-length human CSK was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW= 78 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: CSK is a cytoplasmic tyrosine kinase that has been shown to downregulate the tyrosine kinase activity of the c-src through tyrosine phosphorylation of the c-src carboxy terminus. A yeast 2-hybrid system has been used to identify proteins associated with CSK. The Src homology-3 (SH3) domain of CSK associates with a proline-rich region of PEP, a protein-tyrosine phosphatase expressed in hemopoietic cells.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: CSK c-src tyrosine kinase [ Homo sapiens ]
• Synonyms: CSK; c-src tyrosine kinase; MGC117393; EC 2.7.10.2
• Gene ID: 1445
• mRNA Refseq: NM_001127190
• Protein Refseq: NP_001120662
• MIM: 124095
• UniProt ID: P41240
• Chromosome Location: 15q23-q25
• Pathway: Chemokine signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; Neurotrophin signaling pathway; Regulation of actin cytoskeleton; Integrin cell surface interactions; Signaling in Immune system; Signaling by EGFR
• Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein C-terminus binding; transferase activity