CDK4
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Official Full Name
cyclin-dependent kinase 4 -
Overview
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008] -
Synonyms
CDK4;cyclin-dependent kinase 4;CMM3;PSK-J3;cell division protein kinase 4
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Rhesus macaque
- E.coli
- Insect Cells
- Sf9 Cells
- Wheat Germ
- Mammalian Cells
- HEK293
- Sf21 Cells
- In Vitro Cell Free System
- GST
- His
- T7
- Non
- His&T7
- Avi&Fc&His
- Flag
- DDK&Myc
Involved Pathway
CDK4 involved in several pathways and played different roles in them. We selected most pathways CDK4 participated on our site, such as ATF-2 transcription factor network,B Cell Receptor Signaling Pathway,Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | CDKN2C,H3F3B.1,NUPL2,CNEP1R1,TBC1D8,CLASP1A,NIPBLA,GADD45B,MCM6L,PCNA |
| B Cell Receptor Signaling Pathway | PIK3CG,CD81,CDK7,ARPC3,CR2,DOK1,RAC3,NFATC1,Cd79a,cgr2b |
| Bladder cancer | DAPK3,HBEGF,CCND1,MAPK3,E2F1,CDH1,MMP1,MMP1A,RB1,ARAF |
| Cellular Senescence | PHC1,CDKN2B,H3F3D,HIST1H1B,CBX8B,ASF1A,CBX6A,KAT5,CABIN1,CDKN2C |
| Cell Cycle, Mitotic | CEP70,CDKN2D,DBF4,NEDD1,ENSAA,FGFR1OP,SPDL1,DCTN2,SSNA1,MCM10 |
| ATF-2 transcription factor network | JUN,ATF2,DDIT3,HRK,POU2F1,CREB1,CBFB,KCNA3,DUSP1,RUVBL2 |
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | IRF4,EGR4,EGR2,POU2F1,IKZF1,EGR1,DGKA,CSF2,EGR3,JUNB |
Protein Function
CDK4 has several biochemical functions, for example, ATP binding,cyclin binding,cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK4 itself. We selected most functions CDK4 had, and list some proteins which have the same functions with CDK4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cyclin-dependent protein serine/threonine kinase activity | MOK,CDK9,CDKL3,ICK,CDK2,CDK5,CDK20,CDKL2,CDKL5,CDK13 |
| protein binding | BUD13,THOP1,CCDC64B,TNFRSF14,COX17,NLGN4X,SPON2,CDC34,UBE2D3,POLR2C |
| cyclin-dependent protein serine/threonine kinase regulator activity | FAM58A,CCNL1B,CKS1B,CCNC,CCNT2B,CCNK,PSTPIP2,CCNT1,CCNE2,CCNL1 |
| protein complex binding | MYC,RARB,TMED10,MLC1,Apba1,HCLS1,CPS1,ATM,ITGB1BP1,STRN |
| cyclin binding | CUL3,PTCH1,CDKN1A,CDK14,CDK12,CDK13,CDK6,CDK5RAP3,USP2,HDAC3 |
| ATP binding | HLCS,PKZ,ITGB1BP3,PCCA,CDK15,SETX,NVL,PPP2R4,P2RX5,NADK2 |
Interacting Protein
CDK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK4.
CCND1;CDKN2A
CDK4 Related Signal Pathway
Resources
Research Area
Cancer Drug TargetsIntracellular Kinases in the Akt Pathway
Cyclin-Dependent Protein Kinases (CDKs)
Tumor Antigens
G1 (Restriction) Checkpoints
CDKs (Cyclin Dependent Kinases)
Oncoprotein-Cell Cycle
Related Services
Related Products
References
- Mori, N; Ishikawa, C; et al. Activation of PKC-delta in HTLV-1-infected T cells. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1609-1618(2015).
- Du, ZM; Treiber, D; et al. Use of a Small Molecule Cell Cycle Inhibitor to Control Cell Growth and Improve Specific Productivity and Product Quality of Recombinant Proteins in CHO Cell Cultures. BIOTECHNOLOGY AND BIOENGINEERING 112:141-155(2015).
