CD8A
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Official Full Name
CD8a molecule -
Overview
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CD8A;CD8a molecule;CD8, CD8 antigen, alpha polypeptide (p32) , T cell surface glycoprotein CD8 alpha chain;T-cell surface glycoprotein CD8 alpha chain;T8 T-cell antigen;T cell co-receptor;OKT8 T-cell antigen;T-cell antigen Leu2;Leu2 T-lymphocyte
Recombinant Proteins
- Human
- Mouse
- Ferret
- Cynomolgus
- Rat
- Chicken
- Zebrafish
- Ctenopharyngodon idella
- Bovine
- Golden hamster
- Dog
- Felis catus
- Pongo Pygmaeus
- Mus musculus
- E.coli
- HEK293
- CHO
- C-His-Avi
- Wheat Germ
- Yeast
- Mammalian Cell
- Human Cell
- Mouse
- Human cells
- Human Cells
- In Vitro Cell Free System
- Mammalian cells
- HEK293F
- E.coli expression system
- GST
- His
- His&Flag
- Non
- His&Avi
- His&GST
- His&Fc
- Fc
- Flag
- His&SUMO
- His&Strep II
- C-Twin-Strep
- His&Fc&Avi
Involved Pathway
CD8A involved in several pathways and played different roles in them. We selected most pathways CD8A participated on our site, such as Cell adhesion molecules (CAMs),Antigen processing and presentation,Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD8A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| T cell receptor signaling pathway | CD40LG,PAK6,NRAS,PIK3R2,PDCD1,SLA1,VAV3,CD3G,LCK,PPP3R1 |
| Primary i | LCK,RAG1,PTPRC,RAG2,CD8B1,AIRE,CD4,TAP1,ICOS,CD79A |
| nodeficiency | Cd79a,AIRE,CD19,IGLL1, Cd79b,RAG2,ICOS,CD3E,CD4,DCLRE1C |
| Antigen processing and presentation | IFNG,HSPA1A,HLA-DRA,NFYC,HSPA5,HLA-G,H2-AA,Ctsl,KIR3DL1,HLA-E |
| Cell adhesion molecules (CAMs) | PDCD1LG2,MPZL1L,CLDN5B,NCAM1A,BLA,CD8B1,CNTN1A,GLG1,ICAM2,CLDN23 |
| Hematopoietic cell lineage | CD59,ITGAM,Itga10&Itgb1,CD1C,Itgam&Itgb2,EPO,CD2,CD1D2,Flt3l,CD34 |
Protein Function
CD8A has several biochemical functions, for example, MHC class I protein binding,coreceptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD8A itself. We selected most functions CD8A had, and list some proteins which have the same functions with CD8A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PDLIM5,SYNPO2L,GSTA4,TUB,CUL5,HPCAL1,RND2,MTMR14,CSNK1A1,C10orf28 |
| protein kinase binding | PDPK1,SPDYA,MAG,JAK2,MLKL,TELO2,SREBF1,NME2,CLTC,ATG13 |
| protein homodimerization activity | CALCOCO2,UGT1A3,RNF40,CADM3,LCN2,CADM2A,GSTM3,LRRC41,SLC16A1,STK10 |
| coreceptor activity | PVRL2,CXCR4,IGSF1,CD86,CD28,CCR5,ZP2,NRP1,CCR8,TMIGD2 |
| MHC class I protein binding | CD8B,LILRB2,BCAP31,ATP5A1,CD244,LILRB1,Pilrb1,TAP1,ATP5B,PILRB2 |
Interacting Protein
CD8A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD8A here. Most of them are supplied by our site. Hope this information will be useful for your research of CD8A.
CDK1;q7ckm5_yerpe;y2573_yerpe;CACYBP
Resources
Research Area
B Cell CD AntigenConventional/Classical Dendritic Cells
gamma delta T Cells
Natural Killer T (NKT) Cells
T Cell Antigen Recognition
T Cell Markers
Melanoma Biomarkers
Related Services
Related Products
References
- Chen, SH; Lee, LF; et al. Combination of 4-1BB Agonist and PD-1 Antagonist Promotes Antitumor Effector/Memory CD8 T Cells in a Poorly Immunogenic Tumor Model. CANCER IMMUNOLOGY RESEARCH 3:149-160(2015).
- Furugaki, K; Cui, L; et al. Intraperitoneal Administration of a Tumor-Associated Antigen SART3, CD40L, and GM-CSF Gene-Loaded Polyplex Micelle Elicits a Vaccine Effect in Mouse Tumor Models. PLOS ONE 9:-(2014).
