CALR
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Official Full Name
calreticulin -
Overview
Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. [provided by RefSeq, Jul 2008] -
Synonyms
CALR;calreticulin;RO;CRT;SSA;cC1qR;HEL-S-99n;CRP55;ERp60;HACBP;grp60;calregulin;endoplasmic reticulum resident protein 60;epididymis secretory sperm binding protein Li 99n;Sicca syndrome antigen A (autoantigen Ro;calreticulin)
Recombinant Proteins
- Human
- Rat
- Mouse
- Rabbit
- Cynomolgus
- Rhesus macaque
- Zebrafish
- Chinese hamster
- Pig
- HEK293
- E. coli
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293F
- Human Cell
- Confidential
- Yeast
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- Fc
- His
- GST
- Non
- His&Fc&Avi
- His&SKIK
- Myc&DDK
- N-His&C-Flag
- Flag
Involved Pathway
CALR involved in several pathways and played different roles in them. We selected most pathways CALR participated on our site, such as Protein processing in endoplasmic reticulum,Phagosome,Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CALR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | ATP6V1E1B,CALR3B,DYNC2H1,H2-AB1,RILP,TUBA7L,CANX,RAB7A,HLA-DOA,FCGR3B |
| HTLV-I infection | BCL2L1,HLA-DRA,IKBKB,CCND2,FOS,CDC23,TGFB1,NRP1,PPP3R2,DVL2 |
| Protein processing in endoplasmic reticulum | WFS1,UBE2G1,UBE2J1,UBXN6,HSPA5,MAN1C1,SSR2,HSC70,DNAJC3,LMAN1L |
| Antigen processing and presentation | HLA-A,HSPA6,TAP1,KIR2DS4,TAPBP,NFYC,TNF,H2-AA,HLA-DPB1,HSPA4 |
| Chagas disease (American trypanosomiasis) | FASLG,GNAL,IRAK4,ACE,TGFBR1,PIK3R3,PIK3R5,PPP2R2C,TLR9,MAPK11 |
Protein Function
CALR has several biochemical functions, for example, DNA binding,androgen receptor binding,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CALR itself. We selected most functions CALR had, and list some proteins which have the same functions with CALR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | TNFRSF1B,BLZF1,GLMN,WASH1,KCNH2,CCT2,HSPA9,TRIB3,CD40,CASP10 |
| zinc ion binding | RBM4B,GALT,RNF126,ALPI,ADAM5,SF1,RORAB,PCGF1,TP53I3,ADH1A |
| androgen receptor binding | CTNNB1,FHL2,RAN,PIAS2,SMARCA4,NSD1,PIAS1,CDK7,KDM1A,NRIP1 |
| protein binding involved in protein folding | CD74,CLGN,RIC3,CALR3,PDCL3,PFDN2,HSPA1A,HSPA1B,DNAJB8,PFDN1 |
| peptide binding | PPIA,NPFFR1,ERAP2,CRHBP,PPIB,BDKRB1,CTSB,GPR22,QRFPR,LNPEP |
| hormone binding | MC1R,CRYM,NPR2,GPR30,MC5R,NPR1,ADIPOR1A,TTR,ADIPOR1B,NPR3 |
| DNA binding | IMPDH1,RC3H2,ZNF669,DMRT2B,MCM6L,NKX1.2LA,HOXC8A,DMBX1,THAP2,PRDM10 |
| mRNA binding | LIN28A,RBM4,RBFOX1,NXF2,DPPA5A,DHFRL1,TYMS,NXF3,FYTTD1,RPS5 |
| glycoprotein binding | PLAT,TFR2,Serpina1b,RGMA,SERPINA1A,LCK,ERBB2,STX1A,FOXRED2,PIP |
Interacting Protein
CALR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CALR here. Most of them are supplied by our site. Hope this information will be useful for your research of CALR.
GABARAP;APP;HSPB1;TAP1;p29991-pro_0000037946;env;EIF1B;F8;EPB41;CD40
Resources
Research Area
Angiogenesis InhibitorCalcium-binding Proteins and Related Molecules
Angiogenesis Inhibitor in Cancer
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References
- Wilhelm, M; Lawrence, JJ; et al. Enteric plexuses of two choline-acetyltransferase transgenic mouse lines: Chemical neuroanatomy of the fluorescent protein-expressing nerve cells. BRAIN RESEARCH BULLETIN 111:76-83(2015).
- Vannucchi, AM; Rotunno, G; et al. Calreticulin mutation-specific immunostaining in myeloproliferative neoplasms: pathogenetic insight and diagnostic value. LEUKEMIA 28:1811-1818(2014).
