Asgr1
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Official Full Name
asialoglycoprotein receptor 1 -
Overview
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] -
Synonyms
ASGR1;asialoglycoprotein receptor 1;HL-1;ASGPR;ASGPR1;CLEC4H1;hepatic lectin H1;C-type lectin domain family 4 member H1
Recombinant Proteins
- Mouse
- Human
- Rat
- Mus musculus
- Human Cell
- Mammalian cells
- N-His
- HEK293
- E.coli
- Wheat Germ
- Mammalian Cell
- Yeast
- HEK293T
- Insect Cells
- Mammalian cell
- E.coli expression system
- His
- Fc
- His&Avi
- His&T7
- GST
- Non
- Myc&DDK
- Flag
- C-hFc & C-His
- His&Fc&Avi
- His&Myc
Involved Pathway
Asgr1 involved in several pathways and played different roles in them. We selected most pathways Asgr1 participated on our site, such as Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Asgr1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone synthesis | IYD,GPX2,ATP1B1,PRKCG,DUOX2,ATP1A4,PDIA4,CREB3L2,ASGR2,TSHB |
Protein Function
Asgr1 has several biochemical functions, for example, asialoglycoprotein receptor activity,carbohydrate binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Asgr1 itself. We selected most functions Asgr1 had, and list some proteins which have the same functions with Asgr1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | DMRTB1,EGR2,ALKBH7,CYP46A1.2,ADPRM,PNLIP,ZNF606,ACLYA,SUMF2,ZNF526 |
| carbohydrate binding | SIGLEC14,KLRB1F,CDIPT,GALNT7,GANAB,KLRK1,AIM1,PKD1L2,MAN2C1,KRT1 |
| protein binding | MYCBP2,SYCE1,CA8,TAF8,NUP153,SNRPC,NKX3-1,ZC3H14,AGO1,TEKT5 |
| asialoglycoprotein receptor activity | LRPAP1,ASGR2 |
| protein homodimerization activity | EFR3A,TLR13,PSMD7,UGT1A6A,SLC30A8,CEBPA,CAV2,NOG,NDP,NLRC4 |
Interacting Protein
Asgr1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Asgr1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Asgr1.
CERS2;HIVEP1;CLEC4G;RBBP6;NLK
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