AREG
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Official Full Name
amphiregulin -
Overview
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype. -
Synonyms
AREG;amphiregulin;schwannoma derived growth factor , SDGF;AR;Colorectum cell derived growth factor;CRDGF;A REG;MGC13647;Schwannoma derived growth factor;SDGF;OTTHUMP00000160473;OTTHUMP00000219184;schwannoma-derived growth factor;colorectum cell-derived growth factor;AREGB
Recombinant Proteins
- Human
- Mouse
- Rat
- Cattle
- Mus musculus
- HEK293
- E.coli
- E.Coli/Yeast
- Wheat Germ
- Mammalian Cells
- In Vitro Cell Free System
- Non
- Fc
- His
- GST&His
- His&T7
- GST
- Avi&Fc&His
Involved Pathway
AREG involved in several pathways and played different roles in them. We selected most pathways AREG participated on our site, such as Asparagine N-linked glycosylation,COPII (Coat Protein 2) Mediated Vesicle Transport,Cargo concentration in the ER, which may be useful for your reference. Also, other proteins which involved in the same pathway with AREG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hippo signaling pathway | WNT1,YAP1,TEAD1,PARD3,YWHAB,YWHAG,ITGB2L,FZD8,BMP2,TGFBR1 |
| COPII (Coat Protein 2) Mediated Vesicle Transport | TRAPPC1,NAPG,NAPB,LMAN2L,SERPINA1L,MCFD2,NAPAB,CNIH3,SEC23A,TRAPPC2L |
| ErbB signaling pathway | CAMK2G1,PIK3R2,AKT2L,MAPK9,PRKCG,HRASB,PIK3R1,ERBB4A,HRASA,ERBB3A |
| Cargo concentration in the ER | SEC24A,CTAGE5,CNIH,CNIH2,CTSZ,TMED10,SERPINA1L,PREB,TMED2,CNIH3 |
| ER to Golgi Anterograde Transport | LMAN2L,TRAPPC6A,LMAN2,TRAPPC1,BET1,CTSZ,SERPINA1L,TRAPPC2,NAPAB,TRAPPC3 |
| FSH signaling pathway | CGA,CYP19A1 |
| Asparagine N-linked glycosylation | MAGT1,CNIH3,SCFD1,TRAPPC2,BET1,NEU3,TRAPPC6B,TRAPPC2L,TRAPPC9,PPP6R3 |
Protein Function
AREG has several biochemical functions, for example, cytokine activity,epidermal growth factor receptor binding,growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AREG itself. We selected most functions AREG had, and list some proteins which have the same functions with AREG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | BMP10,IL36RN,GREM1,TNFSF9,Ccl12,Il1f9,Ccl9,IL17D,Ifnz,GM13288 |
| epidermal growth factor receptor binding | Fert2,SHC1,VAV2,TNK2,ARF4,PLSCR1,LINGO1,HBEGF,ATXN2,MS4A1 |
| growth factor activity | CSF3,TGFB1,MIA1,GDF5,MDK,MDKA,NRG4,FGF20A,FIGF,IGF2 |
| protein binding | TMEM242,ADAM8,RPS27,MEIS1,BMPR1A,MRPL49,TBCB,SPRYD7,FLT1,HMGA1 |
Interacting Protein
AREG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AREG here. Most of them are supplied by our site. Hope this information will be useful for your research of AREG.
S100A4;S100A2;S100A5;CCND3;ptsA;UBQLN4
Resources
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References
- Razis, E; Pentheroudakis, G; et al. EGFR gene gain and PTEN protein expression are favorable prognostic factors in patients with KRAS wild-type metastatic colorectal cancer treated with cetuximab. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 140:737-748(2014).
- Strimpakos, A; Pentheroudakis, G; et al. The Prognostic Role of Ephrin A2 and Endothelial Growth Factor Receptor Pathway Mediators in Patients With Advanced Colorectal Cancer Treated With Cetuximab. CLINICAL COLORECTAL CANCER 12:267-274(2013).
