Active Recombinant Human AREG Protein

• Cat.No.: AREG-002H
• Product Overview: The mature recombinant human AR protein containing 98aa (S101-K198) without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Protein Length: 101-198 a.a.
• Description: The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions.
• Bio-activity: Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 5-15 ng/mL.
• Molecular Mass: 11 kDa
• Product-Related Proteins: 101-198
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: AREG amphiregulin [ Homo sapiens (human) ]
• Official Symbol: AREG
• Synonyms: AREG; amphiregulin; AR; SDGF; AREGB; CRDGF; amphiregulin; Names; amphiregulin B; colorectum cell-derived growth factor; schwannoma-derived growth factor
• Gene ID: 374
• mRNA Refseq: NM_001657
• Protein Refseq: NP_001648
• MIM: 104640
• UniProt ID: P15514