ANXA2
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Official Full Name
annexin A2 -
Overview
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ANXA2;annexin A2;ANX2ANX2L4;CAL1H;LPC2D;LIP2;Annexin II;Annexin-2;Calpactin I heavy chain;Calpactin-1 heavy chain;Chromobindin-8;Lipocortin II;Placental anticoagulant protein IV;PAP-IV;Protein I;p36;LPC2;chromobindin 8;OTTHUMP00000163650;calpactin I heavy polypeptide
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- E.coli
- HEK293
- Mammalian Cell
- E. coli
- Wheat Germ
- In Vitro Cell Free System
- HEK293T
- Yeast
- Mammalian cells
- GST
- Non
- His
- His&T7
- Myc&DDK
- Fc
- His&SUMO
- His&Fc&Avi
- Flag
- N-His&C-Myc
- N-His-Myc
Involved Pathway
ANXA2 involved in several pathways and played different roles in them. We selected most pathways ANXA2 participated on our site, such as Dissolution of Fibrin Clot,Hemostasis,Muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Dissolution of Fibrin Clot | SERPINE2,HRG,ANXA2B,S100A10A,S100A10,SERPINF2B,SERPINB8,S100A10B,ANXA2A |
| Muscle contraction | TNNI1B,LMOD1,MYL12A,TNNI2A.4,MYBPC2B,TNNT3A,TNNT3B,MYBPC2,TNNI2A.3,TNNT3 |
| Prostaglandin Synthesis and Regulation | S100A6,ANXA6,ANXA3,ANXA5,S100A10,ANXA4,CC10 |
| Hemostasis | KIF3C,CBX5,HMG20B,MAFGA,CAP1,ANGPT2A,KIF15,DOCK6,ANXA2A,KLC3 |
Protein Function
ANXA2 has several biochemical functions, for example, Rab GTPase binding,S100 protein binding,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA2 itself. We selected most functions ANXA2 had, and list some proteins which have the same functions with ANXA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytoskeletal protein binding | PKD2L1,NF2B,FRMD3,PDLIM3,MYPN,PACSIN1,EPB41L4B,PACSIN2,NCKIPSD,ALDOC |
| protease binding | BCL10,SERPINA1A,BDKRB2,ELANE,FADD,CFLAR,Serpina1b,RFFL,ADAMTS4,CHL1 |
| phosphatidylinositol-4,5-bisphosphate binding | SLC9A1,SESTD1,PARD3,FCHO2,TWF1,MYO1G,TTPA,RAB35,ADAP2,MARK1 |
| calcium-dependent protein binding | NRXN1,CLEC4M,C9orf9,PDCD6,CHP1,PDCD6IP,TNNT3,CPNE3,VPS37B,A2M |
| calcium ion binding | JAG2B,PLCB3,PCDHGA11,LDLRB,SLC24A4,ANXA1,EGFL6,SCUBE3,PRKCSH,DMP1 |
| S100 protein binding | ANXA11,S100A11,AHNAK,KCNK3,S100A1,ATP2A2,FGF1,DDX1,FGF1A,EZR |
| phospholipase A2 inhibitor activity | ANXA1,ANXA3,CC10 |
| protein binding | SPEF1,CYB5R2,BAG6,DHX38,RBPJ,MAGEA8,BRAF,EHD3,TTF2,TTC8 |
| calcium-dependent phospholipid binding | ANXA11B,SYT7B,ANXA1,SYTL2,CPNE3,SYT10,SYT11,ANXA7,ANXA13,SYT12 |
Interacting Protein
ANXA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA2.
PCSK9;MLH1;q99ib8-pro_0000045602;ns3_ns4a_hcvco
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References
- Canas, F; Simonin, L; et al. Annexin A2 autoantibodies in thrombosis and autoimmune diseases. THROMBOSIS RESEARCH 135:226-230(2015).
- Chaudhary, P; Thamake, SI; et al. Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies. BRITISH JOURNAL OF CANCER 111:2328-2341(2014).
