REN
-
Official Full Name
renin -
Overview
Prorenin is a glycosylated aspartic protease that consists of 2?homologouslobes and is the precursor of renin. Renin activates the renin-angiotensinsystem by cleaving angiotensinogen, produced by the liver, to yield angiotensinI, which is further converted into angiotensin II by ACE, theangiotensin-converting enzyme primarily within the capillaries of the lungs. Ithas been reported that the levels of circulating prorenin (but not renin) areincreased in diabetic subjects. -
Synonyms
Prorenin;REN;renin;angiotensinogenase;renin precursor, renal;angiotensin-forming enzyme;HNFJ2;FLJ10761
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Dog
- Rhesus macaque
- Pig
- E.coli
- HEK293
- Mammalian cells
- Human Kidney
- Mammalian Cell
- Yeast
- Human Cell
- HEK293 cells
- HEK
- CHO
- HEK293T
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
REN involved in several pathways and played different roles in them. We selected most pathways REN participated on our site, such as Renin-angiotensin system,Renin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with REN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Renin-angiotensin system | KLK1B8,NLN,ACE,PREP,KLK2,PRCP,KLK1B22,AGTR1A,CPA3,CTSA |
| Renin secretion | PTGER2,PRKACG,PRKG2,GNAQ,CALML3,CALM3,PDE3B,CLCA4,GNAI1,PDE3A |
Protein Function
REN has several biochemical functions, for example, aspartic-type endopeptidase activity,insulin-like growth factor receptor binding,peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by REN itself. We selected most functions REN had, and list some proteins which have the same functions with REN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aspartic-type endopeptidase activity | REN2,DDI1,ANK2B,PGC,Casp3,PGA5,SPPL3,NRIP3,CTSD,SPPL2 |
| insulin-like growth factor receptor binding | IGF2,YWHAH,IRS1,Ren1,ARRB1,INS,INSR,SOCS2,PIK3R1,IGF2B |
| peptidase activity | lon,F2RL1.2,PPPDE1,FURINB,DESI1,PLAUA,PRSS59.1,MMP25,CTSSB.2,MMP13A |
| receptor binding | LPL,NSG1,PVRL3B,NUDT19,ACOT8,PIPOX,TNFSF13B,NPPB,UTS2,PTK6 |
Interacting Protein
REN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with REN here. Most of them are supplied by our site. Hope this information will be useful for your research of REN.
KCTD15
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References
- Pimentel, DC; El Abd, O; et al. Anti-Tumor Necrosis Factor Antagonists in the Treatment of Low Back Pain and Radiculopathy: A Systematic Review and Meta-analysis. PAIN PHYSICIAN 17:E27-E44(2014).
- Volta, V; Ranzato, E; et al. Preclinical Demonstration of Synergistic Active Nutrients/Drug (AND) Combination as a Potential Treatment for Malignant Pleural Mesothelioma. PLOS ONE 8:-(2013).
