PROC
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Official Full Name
protein C (inactivator of coagulation factors Va and VIIIa) -
Overview
Protein?C, also known as autoprothrombin IIA and blood coagulation factor XIV, is a zymogenic (inactive) protein, the activated form of which plays an important role in regulating blood clotting, inflammation, cell death and maintaining the permeability of blood vessel walls in humans and other animals. Activated protein?C (APC) performs these operations primarily by proteolytically inactivating proteins Factor Va and Factor VIIIa. APC is classified as a serine protease, as it contains a residue of serine in its active site. In humans, protein?C is encoded by the PROC gene, which is found on chromosome 2 -
Synonyms
PROC;PROC1;PC;APC;vitamin K-dependent protein C;EC 3.4.21;OTTHUMP00000203820;OTTHUMP00000203827;Blood coagulation factor XIV;Autoprothrombin IIA;Anticoagulant protein C protein C (inactivator of coagulation factors Va and VIIIa);Activation peptide;Anticoagulant protein C;APC;Autoprothrombin IIA;Blood coagulation factor XIV;PC;proC;PROC_HUMAN;PROC1;Protein C (inactivator of coagulation factors Va and VIIIa);THPH3;THPH4;Vitamin K dependent protein C;Protein C
Recombinant Proteins
- Human
- Mouse
- Bovine
- Rat
- Chicken
- Mycobacterium tuberculosis
- Mammalian cells
- CHO
- Plasma
- HEK293
- E.coli
- Mammalian Cell
- Human Cell
- Yeast
- HEK293T
- Mouse Plasma
- Human Plasma
- His
- Non
- His&GST
- His&Myc
- Flag
- His&Fc&Avi
- N-SUMO & C-His
- Myc&DDK
Involved Pathway
PROC involved in several pathways and played different roles in them. We selected most pathways PROC participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with PROC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | CPB2,C1R,C1QA,C7,C8A,MBL1,C4A,GM5077,SERPINA1D,CD46 |
Protein Function
PROC has several biochemical functions, for example, calcium ion binding,protein binding,serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PROC itself. We selected most functions PROC had, and list some proteins which have the same functions with PROC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | PCDHGC5,S100A14,OIT3,S100G,RASGRP3,S100V2,PCDHA2,PRF1,CABP1,PLCH1 |
| protein binding | WDR4,MAMSTR,CIAPIN1,RAMP1,IGF2BP2,RNF2,KLHL41,PRR16,TLE3,TRMT1 |
| serine-type endopeptidase activity | TRY,Prss32,KLK1B3,TMPRSS2,KLK11,MBTPS1,PRSS2,MST1,KLK8,PCSK4 |
Interacting Protein
PROC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PROC here. Most of them are supplied by our site. Hope this information will be useful for your research of PROC.
MMP15;TK1;CSNK2B
Resources
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References
- Dall'Aglio, M; Di Luca, C; et al. Bounds for alpha-optimal partitioning of a measurable space based on several efficient partitions. JOURNAL OF MATHEMATICAL ANALYSIS AND APPLICATIONS 425:854-863(2015).
- Gomes, GMS; Santa-Clara, C; et al. The semigroup ring of a restriction semigroup with an inverse skeleton. SEMIGROUP FORUM 90:449-474(2015).
