Recombinant Human PROC, His-tagged

• Cat.No.: PROC-59H
• Product Overview: Recombinant Human Vitamin K-Dependent Protein C/PROC(Thr19-Pro461), fused with a polyhistidine tag at the C-terminus was expressed in HEK293 Cells.

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Protein Length: 19-461 a.a.
• Description: This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
• Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
• Shipping: The product is shipped on dry ice/ice packs.
• Endotoxin: Less than 0.1 ng/µg (1 IEU/µg).
• OfficialSymbol: PROC

Gene Information

• Gene Name: PROC protein C (inactivator of coagulation factors Va and VIIIa) [ Homo sapiens ]
• Synonyms: PROC; protein C (inactivator of coagulation factors Va and VIIIa); PC; PROC1; Vitamin K-dependent protein C; Autoprothrombin IIA; Anticoagulant protein C; Blood coagulation factor XIV; Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide; EC 3.4.21.69; protein C; protein C (inactivator of coagulation factors Va and VIIIa)
• Gene ID: 5624
• mRNA Refseq: NM_000312
• Protein Refseq: NP_000303
• MIM: 612283
• UniProt ID: P04070
• Chromosome Location: 2q13-q14
• Pathway: Complement and coagulation cascades; Hemostasis; Metabolism of proteins; aling in Immune system
• Function: calcium ion binding; protein binding; serine-type endopeptidase activity