Active Recombinant Human PROC protein, His-tagged

• Cat.No.: PROC-25H
• Product Overview: Recombinant Human PROC(Ala43-Pro461) fused with His tag at C-terminal was expressed in CHO. The isolated protein was activated by thrombin/thrombomodulin complex and further purified.

Specification

• Source: CHO
• Species: Human
• Tag: His
• Predicted N Terminal: Ala43 (light chain) & Leu212 (heavy chain)
• Form: Supplied as a 0.2 μm filtered solution in Tris, NaCl and CaCl2.
• Bio-activity: Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC. The specific activity is >275 pmol/min/µg.
• Molecular Mass: Predicted Molecular Mass: 19 (light chain), 29 (heavy chain) kDa;
  SDS-PAGE: 22-25 kDa and 40-50 kDa, reducing conditions.
• Endotoxin: <1.0 EU per 1 μg of the protein by the LAL method.
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Storage: Avoid repeated freeze-thaw cycles.
  6 months from date of receipt, -20 to -70 centigrade as supplied.
  3 months, -20 to -70 centigrade under sterile conditions after opening.
• Protein length: 43-461 a.a.

Gene Information

• Gene Name: PROC protein C (inactivator of coagulation factors Va and VIIIa) [ Homo sapiens ]
• Official Symbol: PROC
• Synonyms: PROC; protein C (inactivator of coagulation factors Va and VIIIa); vitamin K-dependent protein C; autoprothrombin IIA; anticoagulant protein C; blood coagulation factor XIV; PC; APC; PROC1; THPH3; THPH4
• Gene ID: 5624
• mRNA Refseq: NM_000312
• Protein Refseq: NP_000303
• MIM: 612283
• UniProt ID: P04070
• Chromosome Location: 2q13-q14
• Pathway: Cell surface interactions at the vascular wall, organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; Gamma-carboxylation of protein precursors, organism-specific biosystem