PLAU
-
Official Full Name
plasminogen activator, urokinase -
Overview
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] -
Synonyms
PLAU;PLAU plasminogen activator, urokinase;ATF;UPA;URK;u-PA urokinase-type plasminogen activator;OTTHUMP00000019849;OTTHUMP00000019850;OTTHUMP00000019851;U-plasminogen activator;plasminogen activator, urinary.
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Pig
- Rabbit
- Rat
- Chicken
- Dog
- Cattle
- HEK293
- C-His-Avi
- C-His
- Human urine
- Human
- Insect Cells
- Mammalian Cells
- E.coli
- Human Cells
- Mouse
- Yeast
- His
- Non
- His&T7
- Flag
- His&Fc&Avi
- Myc&DDK
- His&Avi
Involved Pathway
PLAU involved in several pathways and played different roles in them. We selected most pathways PLAU participated on our site, such as NF-kappa B signaling pathway,Complement and coagulation cascades,Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLAU were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MicroRNAs in cancer | CCNE1,NOTCH1,HMOX1,TIMP3,TP53,STMN1,ATM,SHC1,GLS,TPM1 |
| Complement and coagulation cascades | KNG1,F7,LOC100514666,F2,MASP2,TFPI,BDKRB2,F8,C1RA,Serpina1c |
| Proteoglycans in cancer | PTPN11,SLC9A1,WNT7A,SDC2,PPP1R12A,HSPB2,TWIST2,CBLB,TRP53,SDC1 |
| Transcriptional misregulation in cancer | JMJD1C,H3F3A,GZMB,BCL2A1A,IL1R2,RELA,MLLT1,FLT1,DEFA3,SIX4 |
| NF-kappa B signaling pathway | CXCL12,MAP3K7IP3,TICAM2,ATM,LY96,IL1R1,CD40,BTK,IL-8,SYK |
Protein Function
PLAU has several biochemical functions, for example, protein binding,serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLAU itself. We selected most functions PLAU had, and list some proteins which have the same functions with PLAU. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RD3,ARHGAP9,MAPK1,GSDMA2,MZB1,GOLGA2,JRK,FGF19,GSTZ1,DLC1 |
| serine-type endopeptidase activity | KLK1B8,PRSS44,KLK15,PRSS58,PROCA,PRSS12,C1rb,C1S,F2,CMA1 |
Interacting Protein
PLAU has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLAU here. Most of them are supplied by our site. Hope this information will be useful for your research of PLAU.
SERPINE1;MYC;ALAS1;BTK
Resources
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References
- Wang, KP; Zhao, LQ; et al. Differential co-expression analysis of rheumatoid arthritis with microarray data. MOLECULAR MEDICINE REPORTS 10:2421-2426(2014).
- Lu, CH; Lee, RKK; et al. Involvement of the Serine Protease Inhibitor, SERPINE2, and the Urokinase Plasminogen Activator in Cumulus Expansion and Oocyte Maturation. PLOS ONE 8:-(2013).
