Recombinant Human Plasminogen Activator, Urokinase

• Cat.No.: PLAU-2467H
• Product Overview: Recombinant Human plasminogen activator, urokinase was expressed inInsect Cells.MW=18.5 KDa.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Non
• Description: Urokinase-type plasminogen activator is an enzyme that in humans is encoded by the PLAU gene. This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene"s proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
• Concentration: 1.0 mg/ml.
• Volume: 0.1 ml.
• Buffer: 0.1 M Hepes; 0.1 M NaCl; pH 7.4.
• Form: Frozen liquid.
• Shipping Information: Recommended Storage: -70℃;Shipping Conditions: Dry ice; Minimum Shelf Life: 3 years from delivery.

Gene Information

• Gene Name: PLAU plasminogen activator, urokinase [ Homo sapiens ]
• Synonyms: PLAU; plasminogen activator, urokinase; ATF; UPA; URK; u-PA; U-plasminogen activator; plasminogen activator, urinary; urokinase-type plasminogen activator; EC 3.4.21.73; Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B
• Gene ID: 5328
• mRNA Refseq: NM_001145031
• Protein Refseq: NP_001138503
• MIM: 191840
• UniProt ID: P00749
• Chromosome Location: 10q24
• Pathway: Complement and coagulation cascades
• Function: peptidase activity; serine-type endopeptidase a activity