PLAT
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Official Full Name
plasminogen activator, tissue -
Overview
Tissue plasminogen activator (abbreviated TPA or PLAT) is a protein involved in the breakdown of blood clots. It is a serine protease (EC 3.4.21.68) found on endothelial cells, the cells that line the blood vessels. As an enzyme, it catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for clot breakdown. Because it works on the clotting system, tPA is used in clinical medicine to treat only embolic or thrombotic stroke. Use is contraindicated in hemorrhagic stroke and head trauma. -
Synonyms
PLAT;plasminogen activator, tissue;TPA;T-PA;DKFZp686I03148;tissue-type plasminogen activator;alteplase;reteplase;OTTHUMP00000225783;OTTHUMP00000225784;OTTHUMP00000225785;OTTHUMP00000225786;OTTHUMP00000225787;OTTHUMP00000225788;t-plasminogen activator;plasminogen activator, tissue type;tissue plasminogen activator (t-PA)
Recombinant Proteins
- Human
- Pig
- Rabbit
- Rat
- Mouse
- Human Cells
- CHO
- C-His
- Insect Cells
- HEK293
- E.coli
- Mammalian Cells
- Non
- His
- GST&His
- Fc&His
- Fc
- DDK&Myc
- His&SUMO
- Avi&Fc&His
- His&Myc
Involved Pathway
PLAT involved in several pathways and played different roles in them. We selected most pathways PLAT participated on our site, such as Complement and coagulation cascades,Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | C1S,F5,C8B,FGG,C7,SERPINA1,PLAU,F3,C6,Serpina1b |
| Transcriptional misregulation in cancer | PROM1,HIST1H3G,NFKBIZ,CDK14,IGF1,TRP53,RUNX2,LRP2BP,IGF1R,IL-8 |
Protein Function
PLAT has several biochemical functions, for example, glycoprotein binding,phosphoprotein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLAT itself. We selected most functions PLAT had, and list some proteins which have the same functions with PLAT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase activity | TMPRSS13A,GZMH,KLK14,MCPT8,F11,PRSS39,F9A,FAM108A1,PRSS27,CTSC |
| glycoprotein binding | RASA1,LRRK2,LGALS1,TGFB1,SERPINA1E,TFRC,FLNA,CDH1,VIM,F7 |
| protein binding | SMAD1,HSPB11,CRYAB,PIK3R3,DNMT3A,LDB3,ATP2B1,ADNP,SLC6A18,FAM127B |
| receptor binding | TAC4,BMP3,MSTN,PECI,FGF13A,ANGPTL2,ANKRD13C,PTK2AA,TNFSF8,SNX17 |
| phosphoprotein binding | PITX2,DPYSL3,MTOR,LYN,SRC,PKD2,MID1,YWHAE,SFN,TBK1 |
Interacting Protein
PLAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLAT here. Most of them are supplied by our site. Hope this information will be useful for your research of PLAT.
SERPINE1;Plgrkt
Resources
Research Area
Serine Proteases and RegulatorsEndothelial Cell Coagulation Molecules
Inflammatory Mediators
Fibrinolysis System
Coagulation Cascade Proteases
Plasmin/Plasminogen and Kallikrein/Kinin Systems
Glioma Biomarkers
Related Services
Related Products
References
- Jiang, WL; Zheng, Z; et al. Demodulation for hydraulic pump fault signals based on local mean decomposition and improved adaptive multiscale morphology analysis. MECHANICAL SYSTEMS AND SIGNAL PROCESSING 58-59:179-205(2015).
- Didenko, AN; Vodovozov, VY; et al. Paleomagnetism of the Ulkan massif (SE Siberian platform) and the apparent polar wander path for Siberia in late Paleoproterozoic-early Mesoproterozoic times. PRECAMBRIAN RESEARCH 259:58-77(2015).
