Recombinant Human Plasminogen Activator, Tissue

• Cat.No.: PLAT-1292H
• Product Overview: Recombinant Human PLATNon-Cleavable, and the addition of a R257E mutation generates human PLAT thatis 100% single chain and resistant to cleavage by plasmin.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Non
• Description: Tissue plasminogenactivator (abbreviated tPA or PLAT) is a protein involved in the breakdown ofblood clots. It is a serine protease found on endothelial cells, the cellsthat line the blood vessels. As an enzyme, it catalyzes the conversion ofplasminogen to plasmin, the major enzyme responsible for clot breakdown.Because it works on the clotting system, PLATis used in clinical medicine to treat only embolic or thrombotic stroke. Useis contraindicated in hemorrhagic stroke and head trauma.
• Form: Liquid in 0.4 MHEPES + 0.1 M NaCl, pH 7.4
• Molecular Weight: 70.0 kDa
• Concentration: 2.0 mg/ml
• Storage: Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: PLAT

Gene Information

• Gene Name: PLAT plasminogen activator,tissue [ Homo sapiens ]
• Synonyms: PLAT; plasminogenactivator, tissue; TPA; T-PA; DKFZp686I03148; tissue-type plasminogenactivator; alteplase; reteplase; OTTHUMP00000225783; OTTHUMP00000225784;OTTHUMP00000225785; OTTHUMP00000225786; OTTHUMP00000225787;OTTHUMP00000225788; t-plasminogen activator; plasminogen activator, tissuetype; tissue plasminogen activator (t-PA); EC 3.4.21.68
• Gene ID: 5327
• mRNA Refseq: NM_000930
• Protein Refseq: NP_000921
• MIM: 173370
• UniProt ID: P00750
• Chromosome Location: 8p12
• Pathway: Blood ClottingCascade; Complement and Coagulation Cascades; Dissolution of Fibrin Clot;Endochondral Ossification; Hemostasis; Selenium Pathway; Senescence and Autophagy;Signal Transduction; Signaling by PDGF; amb2 Integrin signaling
• Function: peptidase activity;protein binding; serine-type endopeptidase activity