KCNS1
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Official Full Name
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 -
Overview
Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. -
Synonyms
KCNS1;potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1;potassium voltage-gated channel subfamily S member 1;Kv9.1;Delayed rectifier K(+) channel alpha subunit 1;Delayed-rectifier K(+) channel alpha subunit 1;K+ voltage gated channel, subfamily S, 1;KCNS1_HUMAN;OTTHUMP00000031783;potassium voltage gated channel delayed rectifier protein;potassium voltage gated channel delayed rectifier protein S1;potassium voltage gated channel, delayed rectifier, subfamily S, member 1;voltage gated potassium channel protein Kv9.1;Voltage gated potassium channel subunit Kv9.1;Voltage-gated potassium channel subunit Kv9.1;delayed-rectifier K+ channel alpha subunit 1;voltage-gated potassium channel protein Kv9.1
Recombinant Proteins
- Rhesus macaque
- Rat
- Mouse
- Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
- Pongo Abelii
- Mus musculus
- Lemur catta (Ring-tailed lemur)
- Colobus guereza (Mantled guereza) (Eastern black-and-white colobus monkey)
- Macaca mulatta
- Human
- Papio anubis (Olive baboon)
- Chlorocebus Aethiops
- Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
- Aotus nancymaae (Ma's night monkey)
- Pan troglodytes
- Gorilla gorilla gorilla (Western lowland gorilla)
- Mammalian Cells
- HEK293
- E.coli
- His
- His&Fc&Avi
Involved Pathway
KCNS1 involved in several pathways and played different roles in them. We selected most pathways KCNS1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
KCNS1 has several biochemical functions, for example, acetylcholine receptor binding,protein phosphatase type 1 regulator activity,ubiquitin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNS1 itself. We selected most functions KCNS1 had, and list some proteins which have the same functions with KCNS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acetylcholine receptor binding | RIC3,UBXN2A,RAPSN,DLG4,RER1,JAK2,NRXN1,APP |
| ubiquitin binding | BRAP,USP16,USP13,SIRT2,VPS28,UBXN2A,FAF2,UBE2N,OTUB1,TOM1L1 |
| protein phosphatase type 1 regulator activity | PPP1R15A,PPP1R8,PHACTR3A,PHACTR3B,WBP11,PHACTR3,UBXN2A,PPP1R7,PPP1R16A,NSFL1C |
Interacting Protein
KCNS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNS1.
Resources
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References
- Langford, DJ; West, C; et al. Variations in Potassium Channel Genes Are Associated With Breast Pain in Women Prior to Breast Cancer Surgery. JOURNAL OF NEUROGENETICS 28:122-135(2014).
