IL12A
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Official Full Name
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) -
Overview
Interleukin 12 (IL12) is an important cytokine produced by a variety of immune effector cells that leads to a type 1 helper T cell (Th1) response. IL12 also directs T cells to the skin via induction of cutaneous lymphocyte antigen (CLA) expression. Interleukin 12 is a heterodimeric cytokine (p70), composed of two covalently linked subunits, p35 and p40. -
Synonyms
IL12A;interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35);NKSF1;interleukin-12 subunit alpha;CLMF;cytotoxic lymphocyte maturation factor 1;p35;IL 12;subunit p35;IL 12A;IL35 subunit;interleuk
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Cynomolgus
- Rhesus macaque
- Rat
- Chicken
- Pig
- Dog
- HEK293
- Insect Cells
- E.coli
- CHO
- Mammalian Cells
- Human Cells
- Sf9 Cells
- Sf21 Cells
- Yeast
- Fc
- His
- Non
- Fc&His
- His&S
- His&T7
- Avi&Fc&His
- His&Strep
- Strep
- His&Twin Strep
Involved Pathway
IL12A involved in several pathways and played different roles in them. We selected most pathways IL12A participated on our site, such as Cytokine-cytokine receptor interaction,Toll-like receptor signaling pathway,RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | IL19,CCR6,CCL3,CCL21,IFNA21,CCL7,IFNA16,CCR3,IL1RAP,GM-CSF |
| Inflammatory bowel disease (IBD) | IL23R,IL18RAP,Il4ra,IL4,HLA-DMB,TGFB3,GATA3,HLA-DRA,IL2RG,TGFB2 |
| Tuberculosis | IFNA5,HLA-DQA2,STAT1,ITGB2,MAPK11,H2-AB1,LBP,IFNA6,HLA-DOB,CD209B |
| Type I diabetes mellitus | HLA-A,FAS,HLA-DRB4,HLA-DQA2,CD80,PTPRN,IL1B,HLA-DRB1,H2-AB1,HLA-DRB5 |
| Jak-STAT signaling pathway | IFNA17,SOCS6B,IL11RA,PIAS2,IL10RA,MCL1A,IL27RA,IL5RA,STAT4,AOX4 |
| Leishmaniasis | FCGR3,ITGB2,HLA-DQA1,TLR2,HLA-DQB1,TRAF6,IL1B,FCGR4,NCF4,Itgam&Itgb2 |
| Allograft rejection | PRF1,HLA-F,HLA-DQA1,IL10,CD28,TNF,HLA-DRA,CD80,HLA-E,HLA-DPB1 |
| Chagas disease (American trypanosomiasis) | C3,GNAI2,TGFBR1,TGFB2,IL1B,CCL5,CALR,PPP2R2B,CCL2,MAPK8 |
| RIG-I-like receptor signaling pathway | TBKBP1,IL12B,MAPK8,IFNA3,NFKBIAB,CASP8,IL-8,ATG5,RIPK1,TMEM173 |
Protein Function
IL12A has several biochemical functions, for example, contributes_to cytokine activity,contributes_to growth factor activity,interleukin-12 beta subunit binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL12A itself. We selected most functions IL12A had, and list some proteins which have the same functions with IL12A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-12 receptor binding | IL12BA,JAK2,IL12B |
| protein binding | GUCY1A3,SYNPO2L,CALR,TUT1,ZZZ3,SIRT1,C5orf24,FKBP5,DDR2,CAPN2 |
| protein heterodimerization activity | H3F3A,NFYBA,CHRAC1,SNX1,PPP1CBL,POLA1,HMG20B,BMP7A,ADRB1,CAV1 |
| contributes_to cytokine activity | CLCF1,IL12B,CRLF1 |
| contributes_to growth factor activity | IL12B |
Interacting Protein
IL12A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12A.
IL12B;IL12RB1
IL12A Related Signal Pathway
Resources
Research Area
gamma delta T CellsAutoimmune Disease Therapeutic Targets
Inflammatory Bowel Diseases Therapeutic Targets
Rheumatoid arthritis Therapeutic Targets
IL-12 Family Ligands
Related Services
Related Products
References
- Senapati, S; Gutierrez-Achury, J; et al. Evaluation of European coeliac disease risk variants in a north Indian population. EUROPEAN JOURNAL OF HUMAN GENETICS 23:530-535(2015).
- Ruffell, B; Chang-Strachan, D; et al. Macrophage IL-10 Blocks CD8(+) T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells. CANCER CELL 26:623-637(2014).
