HSD11B1
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Official Full Name
hydroxysteroid (11-beta) dehydrogenase 1 -
Overview
11β-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers. The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
11-DH;11-beta-HSD1;CORTRD2;HDL;HSD11;HSD11B;HSD11L;SDR26C1;corticosteroid 11-beta-dehydrogenase isozyme 1;short chain dehydrogenase/reductase family 26C, member 1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Sheep
- Mus musculus
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- E.coli expression system
- His
- Non
- GST
- His&Strep
- His&Fc&Avi
- Myc&DDK
- Flag
- His&SUMO
Involved Pathway
HSD11B1 involved in several pathways and played different roles in them. We selected most pathways HSD11B1 participated on our site, such as Steroid hormone biosynthesis,Metabolism of xenobiotics by cytochrome P,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD11B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | SRM,TPI1,COX8A,CKMT1A,CYP27B1,PAPSS1,PGK2,STT3B,NOS1,PYCR1B |
| Metabolism of xenobiotics by cytochrome P | CBR3,GSTA1,SULT2A1,UGT1A7C,GSTM1,GSTT2,AKR7A2,GSTM2,CBR1L,GSTA |
| Chemical carcinogenesis | UGT1A7C,GSTT1,ALDH3B2,CYP3A43,CYP2C54,UGT1A4,CYP2C8,ADH1C,GSTK1,GSTM4 |
| Steroid hormone biosynthesis | CYP3A41B,CYP21A1,HSD17B7,COMTB,CYP2D9,HSD17B12A,SRD5A2A,CYP2C70,UGT1A9,UGT1A7C |
Protein Function
HSD11B1 has several biochemical functions, for example, 11-beta-hydroxysteroid dehydrogenase (NADP+) activity,11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD11B1 itself. We selected most functions HSD11B1 had, and list some proteins which have the same functions with HSD11B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity | HSD11B2 |
Interacting Protein
HSD11B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD11B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD11B1.
GKAP1
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