HDAC8
-
Official Full Name
histone deacetylase 8 -
Overview
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] -
Synonyms
HDAC8;histone deacetylase 8;HD8;WTS;RPD3;CDA07;CDLS5;MRXS6;HDACL1;histone deacetylase-like 1;Wilson-Turner X-linked mental retardation syndrome;Wilson-Turner syndrome (mental retardation, X-linked, syndromic-6, with gynecomastia and obesity)
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Insect Cells
- Sf21 Insect Cell
- Insect Cell
- HEK293 cells
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- S.frugiperda
- Insect cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- His&SUMO
Involved Pathway
HDAC8 involved in several pathways and played different roles in them. We selected most pathways HDAC8 participated on our site, such as Alcoholism,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral carcinogenesis | TP53,PIK3R5,NRAS,GTF2H2C_2,HIST1H4E,VDAC3,TRP53,ACTN3,SRC,CCND3 |
| Alcoholism | HIST2H4A,HIST1H2AJ,ATF4,HIST1H4L,HIST1H2BJ,GM14477,GNG13,GNG2,HIST1H2BA,HIST2H2BE |
Protein Function
HDAC8 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific),histone deacetylase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC8 itself. We selected most functions HDAC8 had, and list some proteins which have the same functions with HDAC8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone deacetylase activity | ATXN3L,HDAC9B,SIRT2,HDAC7,SIRT1,MTA2,HDAC5,HDAC9,HDAC3,HDAC2 |
| transcription factor binding | PDX1,E2F1,HDAC5,DDIT3,IFT172,MED12L,RBL1,HYAL1,TCF12,PER1 |
| metal ion binding | PRKCBP1L,ZFP507,U2AF1,COX5A,ETFDH,C6AST3,Car9,RASAL1,RNF222,TRIM35-23 |
| NAD-dependent histone deacetylase activity (H3-K14 specific) | HDAC1,HDAC11,HDAC3,HDAC7A,HDAC6,HDAC5,HDAC4,HDAC10,HDAC7,HDAC9B |
Interacting Protein
HDAC8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC8 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC8.
TP53;STAT3;bmf_human_gene;SEC16A;CPNE3;SVIL;TPM3;MME;NUP98;TPM4;SMC1A;CROCC;ZSCAN2;STAG2;MDM1;CHCHD3;ADD3;SMC3
HDAC8 Related Signal Pathway
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