Recombinant Human HDAC8, His-tagged

• Cat.No.: HDAC8-13711H
• Product Overview: Recombinant Human HDAC8 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-377a.a.
• Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: HDAC8 histone deacetylase 8 [ Homo sapiens ]
• Official Symbol: HDAC8
• Synonyms: HDAC8; histone deacetylase 8; HDACL1, histone deacetylase like 1; RPD3; histone deacetylase-like 1; HD8; CDA07; HDACL1
• Gene ID: 55869
• mRNA Refseq: NM_001166418
• Protein Refseq: NP_001159890
• MIM: 300269
• UniProt ID: Q9BY41
• Chromosome Location: Xq13
• Pathway: Cell cycle, organism-specific biosystem; NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by NOTCH, organism-specific biosystem; Signaling by NOTCH1, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem
• Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; histone deacetylase activity (H3-K16 spe