Recombinant Human HDAC8 Protein, His-tagged

• Cat.No.: HDAC8-125H
• Product Overview: Active recombinant C-terminal His-tag full length human HDAC8 protein (2-377) was expressed in E. coli.

Specification

• Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 45.3 kDa
• Protein length: 2-377
• Purity: ≥85% estimated by SDS-PAGE
• Unit Definition: One unit is the amount of enzyme required to release 1 nmol/min acetate from 100 μM acetylated p53 peptide at 37 centigrade in 25 mM Tris, pH 8.0, 137 mM NaCl, 2.7 mM KCl, and 1 mM MgCl2.
• Stability: ≥ 6 months
• Storage: At -80 centigrade.
• Storage Buffer: 50 mM Tris, pH 7.5, with 200 mM sodium chloride 2.5 mM potassium chloride, 1 mM TCEP, 25% glycerol

Gene Information

• Gene Name: HDAC8 histone deacetylase 8 [ Homo sapiens (human) ]
• Official Symbol: HDAC8
• Synonyms: HDAC8; histone deacetylase 8; HD8; WTS; RPD3; CDA07; CDLS5; KDAC8; MRXS6; HDACL1; histone deacetylase 8; histone deacetylase-like 1; EC 3.5.1.98
• Gene ID: 55869
• mRNA Refseq: NM_018486
• Protein Refseq: NP_060956
• MIM: 300269
• UniProt ID: Q9BY41